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The protein encoded by YY2 is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. Additionally we are shipping YY2 Antibodies (19) and many more products for this protein.
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article summarizes all critical aspects that are (or will be) relevant for a better understanding of YY1 (show YY1 Proteins)- and/or YY2-mediated cellular control mechanisms
Results show that human YY2 is not redundant to YY1 (show YY1 Proteins), and YY2 is a significant regulator of genes previously identified as uniquely responding to YY1 (show YY1 Proteins).
YY2 can bind to and regulate some promoters known to be controlled by YY1 (show YY1 Proteins). Similar to YY1 (show YY1 Proteins), YY2 contains both transcriptional activation and repression functions.
the novel factor YY2 antagonizes the negative actions exerted by YY1 (show YY1 Proteins)
yy2 expression is mediated by its own methylation-sensitive promoter.
both the up- and down-regulation of yy2 significantly impairs the outgrowth of the major neurite of primary hippocampal neurons and the numbers of neuronal processes in proximate extensions
Yy2 expression in the heart and lung is constitutively expressed during embryogenesis and in adult mice. Developmental changes of yy2 transcription became obvious in various areas of the brain.
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14.
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