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Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Additionally we are shipping ZCCHC6 Proteins (3) and many more products for this protein.
Showing 5 out of 6 products:
Human Polyclonal ZCCHC6 Primary Antibody for ICC, IF - ABIN4366752
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6 (show IL6 Antibodies), CXCL1 (show CXCL1 Antibodies), and CXCL5 (show CXCL5 Antibodies). These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
The authors found that TUT4 (show ZCCHC11 Antibodies)(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
Knockdown of 3'hExo (show ERI1 Antibodies) also altered the uridylation of histone mRNAs, suggesting that TUT7 and 3'hExo (show ERI1 Antibodies) function together in trimming and uridylating histone mRNAs
Study identified TUT4 (show ZCCHC11 Antibodies) and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
Study identified TUT7, TUT4 (show ZCCHC11 Antibodies), and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 (show LIN28A Antibodies) uses two different TUTases to control let-7 expression .
Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation (By similarity).
PAP associated domain containing 6
, TUTase 7
, terminal uridylyltransferase 7
, zinc finger CCHC domain-containing protein 6