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May be involved in transcriptional regulation.. Additionally we are shipping ZNF224 Antibodies (30) and many more products for this protein.
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we showed that ZNF224 positively modulates cyclin D3 (show CCND3 Proteins) gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer
Data show that Wilms' tumor 1 (show WT1 Proteins) protein (WT1 (show WT1 Proteins))binds to the zinc finger protein 224 (ZNF224) promoter and represses ZNF224 expression.
ZNF224 acts in fine tuning of WT1 (show WT1 Proteins)-dependent control of gene expression, acting as a co-activator of WT1 (show WT1 Proteins) in the regulation of proapoptotic genes and suppressing WT1 (show WT1 Proteins) mediated transactivation of antiapoptotitc genes.
REVIEW: ZNF224 is a multifunctional protein and alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity
ZNF224 acts as a transcriptional co-regulator of WT1 (show WT1 Proteins).
Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 (show DEPDC1 Proteins) interacted and colocalized with zinc finger transcription factor (show OSR1 Proteins) ZNF224, a known transcriptional repressor.
Results suggest that bone marrow zinc finger 2 (BMZF2) interferes with the transactivation potential of Wilms tumor suppressor gene (WT1 (show WT1 Proteins)).
We demonstrate that ZNF224, a Kruppel-like zinc finger transcription factor, is the repressor protein that specifically binds to the negative cis-element AldA-NRE and affects the AldA-NRE-mediated transcription
Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Kruppel-like zinc-finger protein family.
May be involved in transcriptional regulation.
bone marrow zinc finger 2
, zinc finger 2, bone marrow
, zinc finger protein 233
, zinc finger protein 255
, zinc finger protein 27 (KOX 22)
, zinc finger protein KOX22
, zinc finger protein ZNF255
, protein mKR4