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Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow.
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ZNF467 gene DNA methylation (show HELLS Proteins) is importants in the pathogenesis of idiopathic pulmonary fibrosis.
These results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export.
these results indicate that Zfp467 regulates the differentiation of adipose-derived stem cells via a mechanism involving Sost (show SOST Proteins)-mediated inhibition of Wnt (show WNT2 Proteins) signaling, suggesting potential therapeutic targets for the treatment of osteoporosis.
Zfp467 play an important role in adipose derived stem cells differentiation to adipocyte and osteoblast.
Zfp467 is a novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation
EZI. EZI is a novel nuclear zinc finger protein that augments STAT3 (show STAT3 Proteins) activity by keeping it in the nucleus.
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).
zinc finger protein EZI
, endothelial cell-derived zinc finger protein