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Transcriptional regulator involved in developmental processes. Additionally we are shipping Zinc Finger Protein 537 Proteins (3) and many more products for this protein.
Showing 10 out of 26 products:
Human Polyclonal ZNF537 Primary Antibody for IHC (p), WB - ABIN1450132
Santos, Fonseca, Vieira, Vieira, Casares: Phylogeny of the teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3b in the zebrafish. in Developmental dynamics : an official publication of the American Association of Anatomists 2010
Show all 5 references for ABIN1450132
Human Polyclonal ZNF537 Primary Antibody for WB - ABIN2777681
Nagase, Kikuno, Ishikawa, Hirosawa, Ohara: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 2000
suggest a novel mechanism for transcriptional repression by TSHZ3 in which TSHZ3 and BAF57 (show SMARCE1 Antibodies) cooperate to modulate MyoD (show MYOD1 Antibodies) activity on the Myog (show MYOG Antibodies) promoter to regulate skeletal muscle differentiation.
Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.
Mice that are null (show tshz2 Antibodies) mutant for the Teashirt3 (Tshz3) gene exhibit congenital pelvi-ureteric junction obstruction with defective smooth muscle differentiation and absent peristalsis in the proximal ureter.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
ureteric smooth muscle cell precursors express the transcription factor teashirt 3 (TSHZ3), and Tshz3-null mutants have congenital hydronephrosis without anatomical obstruction
The dynamic expression of Sox9 (show SOX9 Antibodies) and the interaction between TSHZ3, SOX9 (show SOX9 Antibodies) and MYOCD (show MYOCD Antibodies) provide a mechanism that regulates the pace the myogenic program in the ureter.
TSHZ3 gene promoter was found to be methylated in all the breast/prostate cancer cell lines and some of the breast cancer clinical specimens while the TSHZ2 (show tshz2 Antibodies) gene promoter was unmethylated except for the MDA-MB-231 breast cancer cell line.
Mutations in TSHZ2 (show tshz2 Antibodies) and TSHZ3 are not a major cause of pelvi-ureteric junction obstruction, at least in Albanian and Macedonian populations.
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity).
teashirt family zinc finger 3
, zinc finger protein 537
, teashirt 3
, teashirt homolog 3
, teashirt zinc finger family member 3