beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 Proteins (B4GALNT1)

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. Additionally we are shipping B4GALNT1 Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
B4GALNT1 2583 Q00973
B4GALNT1 14421 Q09200
B4GALNT1 64828 Q10468
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Top B4GALNT1 Proteins at

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

B4GALNT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
Rat (Rattus)

More Proteins for beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) Interaction Partners

Human beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) interaction partners

  1. Data suggest that ganglioside glycosyltransferases ST3GAL5 (show ST3GAL5 Proteins), ST8SIA1 (show ST8SIA1 Proteins), and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II (show ST3GAL2 Proteins) is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II (show ST3GAL2 Proteins), dimer formation controls their S-acylation status.

  2. Novel B4GALNT1 mutations reported in two families with hereditary spastic paraplegia.

  3. The resukts of this study identified mutations in B4GALNT1 (GM2 (show CYB5D2 Proteins) synthase), encoding the enzyme that catalyzes the second step in complex ganglioside biosynthesis, as the cause of this neurodegenerative phenotype.

  4. Minimally disseminated disease in high risk retinoblastoma patients was detected using reverse transcriptase PCR for GD2 synthase mRNA in CSF (show CSF2 Proteins).

  5. Molecular upstaging of GalNAc-T using rt-pcr was correlated with prognosis in melanoma patients

  6. GD2/GM2 (show CYB5D2 Proteins) is not a reliable biomarker in small cell lung carcinoma

  7. The expression of three messengers coding for SAT-1 (show SAT1 Proteins), SAT-2 (show SLC38A2 Proteins) and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated.

  8. Transmission disequilibrium test and case-control analysis did not detect an association of B4GALNT1 gene with T1DM.

Mouse (Murine) beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) interaction partners

  1. GM2 (show CYB5D2 Proteins) elevation is associated with activation of microglia and astrocytes in the injured developing brain, and GM2 (show CYB5D2 Proteins), GD2, or other downstream gangliosides may regulate astroglial responses in ethanol-induced neurodegeneration

  2. This study demonistrated that Ganglioside deficiency(B4galnt1 and ST8SIA1 (show ST8SIA1 Proteins) knockout mice causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.

  3. Galgt1 is required for presynaptic expression of the CT carbohydrate at the neuromuscular junction.

  4. Impaired hippocampal long-term potentiation and failure of learning in beta1,4-N-acetylgalactosaminyltransferase (show CSGALNACT1 Proteins) gene transgenic mice

  5. To define maturation of cortical neurons in mice lacking B4galnt1 we performed a morphological analysis of Golgi-Cox (show CPOX Proteins) impregnated pyramidal neurons.

  6. Our data indicate that it is highly unlikely that transmission failure at NMJs contributes to the progressive motor defects of aged GM2/GD2-synthase null-mutants.

  7. In GalNAc-T(-/-) mice, the number of degenerated axons was increased in the dorsal funiculus, tract of Lissauer, and dorsolateral funiculus of the cervical spinal cord as well as the dorsal funiculus and tract of Lissauer of the lumbar segment

  8. Increased 9-O-acetyl GD3, in addition to GM3 (show GRM6 Proteins) and GD3, may play an important role in the compensation for deleted complex gangliosides in the mutant mice.

B4GALNT1 Protein Profile

Protein Summary

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with B4GALNT1

  • beta-1,4-N-acetyl-galactosaminyl transferase 1 (b4galnt1)
  • beta-1,4-N-acetyl-galactosaminyl transferase 1a (b4galnt1a)
  • Beta-1,4 N-acetylgalactosaminyltransferase 1 (b4gn1)
  • beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4GALNT1)
  • beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4galnt1)
  • 4933429D13Rik protein
  • B4GALNT1 protein
  • Gal-NAc-T protein
  • GALGT protein
  • Galgt1 protein
  • GalNAc-T protein
  • GalNAcT protein
  • Ggm-2 protein
  • Ggm2 protein
  • MGC53523 protein
  • SPG26 protein
  • zgc:158609 protein

Protein level used designations for B4GALNT1

beta-1,4-N-acetyl-galactosaminyl transferase 1 , beta-1,4 N-acetylgalactosaminyltransferase 1 , Beta-1,4 N-acetylgalactosaminyltransferase 1 , beta-1,4 N-acetylgalactosaminyltransferase 1-like , (N-acetylneuraminyl)-galactosylglucosylceramide , GD2 synthase, GM2 synthase , GM2/GD2 synthase , UDP-Gal:betaGlcNAc beta-1,4-N-acetylgalactosaminyltransferase transferase 1 , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (GalNAc-T) , beta1,4GalNAc-T , beta1-4GalNAc-T , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase , beta1,4GalNAC-T , beta-4N-acetylgalactosaminyltransferase

379299 Xenopus laevis
558684 Danio rerio
100145208 Xenopus (Silurana) tropicalis
100306792 Salmo salar
100441953 Pongo abelii
100516440 Sus scrofa
2583 Homo sapiens
481129 Canis lupus familiaris
520159 Bos taurus
14421 Mus musculus
64828 Rattus norvegicus
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