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gamma-aminobutyric Acid (GABA) B Receptor, 2 Proteins (GABBR2)

The multi-pass membrane protein encoded by GABBR2 belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. Additionally we are shipping GABBR2 Antibodies (173) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat GABBR2 GABBR2 83633 O88871
GABBR2 9568 O75899
GABBR2 242425 Q80T41
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Top GABBR2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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HOST_Escherichia coli (E. coli) Cat Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

GABBR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) Interaction Partners

Human gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) interaction partners

  1. The rare variants in GABBR2 were significantly associated with smoking status.

  2. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (show CA2 Proteins)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (show PLC Proteins) activation pathway.

  3. Putative GABAA (show GABRg1 Proteins) and ASIC1a (show ACCN2 Proteins) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  4. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity

  5. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.

  6. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system.

  7. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 (show GABRA3 Proteins) and GABBR2 genes.

  8. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders.

  9. GABA(B) receptor subunit 2 (show CCT2 Proteins) levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls.

  10. variants of GABBR1 (show GABBR1 Proteins) and GABBR2 are associated with nicotine dependence in European- and African-American populations

Mouse (Murine) gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) interaction partners

  1. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (show PRKCG Proteins) but decreased that of GABABR1 (show GABBR1 Proteins) and GABABR2 at both protein and mRNA levels in the CNC

  2. GABABR2 has a role as a regulator of glutamine synthetase (show GLUL Proteins) stability

  3. siRNA knock-down of NgR1 (show NEUROG1 Proteins) resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1 (show KCNJ3 Proteins).

  4. Cadm1 (show CADM1 Proteins) specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum.

  5. Gabbr1 (show GABBR1 Proteins) and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers

  6. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 (show BMP2 Proteins) expression toward disturbance of osteoclastogenesis after down-regulation of RANKL (show TNFSF11 Proteins) expression in mouse bone.

  7. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 (show GABBR1 Proteins) protein levels in mouse brains during postnatal development in vivo

  8. Our data suggest that association of GABAB(2) with GABAB(1 (show GABBR1 Proteins)) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits.

  9. Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1 (show MAPK3 Proteins)/2) phosphorylation in cultured cerebellar granule neurons.

  10. GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex.

GABBR2 Protein Profile

Protein Summary

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Gene names and symbols associated with GABBR2

  • gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2)
  • gamma-aminobutyric acid (GABA) B receptor, 2 (gabbr2)
  • gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2)
  • gamma-aminobutyric acid (GABA) B receptor, 2 (Gabbr2)
  • GABA(B)R2 protein
  • GABABR2 protein
  • Gb2 protein
  • Gm425 protein
  • GPR51 protein
  • GPRC3B protein
  • HG20 protein
  • HRIHFB2099 protein
  • si:dkey-190l1.2 protein

Protein level used designations for GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2 , gamma-aminobutyric acid type B receptor subunit 2-like , G protein-coupled receptor 51 , G-protein coupled receptor 51 , GABA-B R2 receptor , GABA-B receptor 2 , GABA-B-R2 , GABA-BR2 , GABABR2 , gamma-aminobutyric acid type B receptor subunit 2 , gb2 , GABA-B receptor, R2 subunit , gamma-aminobutyric acid B receptor 2 , gamma-aminobutyric acid type B receptor, subunit 2 , ortholog of human G protein-coupled receptor 51 GPR51

GENE ID SPECIES
100063963 Equus caballus
100346845 Oryctolagus cuniculus
100374110 Saccoglossus kowalevskii
100412651 Callithrix jacchus
100448699 Pongo abelii
100476699 Ailuropoda melanoleuca
100561239 Anolis carolinensis
100591607 Nomascus leucogenys
83633 Rattus norvegicus
9568 Homo sapiens
242425 Mus musculus
733216 Xenopus laevis
420979 Gallus gallus
517040 Bos taurus
481627 Canis lupus familiaris
560267 Danio rerio
100511175 Sus scrofa
100170764 Cavia porcellus
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