Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Proteins (4) and ATRX Kits (1) and many more products for this protein.
Showing 10 out of 94 products:
Human Monoclonal ATRX Primary Antibody for ELISA, WB - ABIN393693
Kernohan, Jiang, Tremblay, Bonvissuto, Eubanks, Mann, Bérubé: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. in Developmental cell 2010
Show all 5 references for ABIN393693
Human Polyclonal ATRX Primary Antibody for ICC, IF - ABIN442805
Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015
Show all 2 references for ABIN442805
Human Polyclonal ATRX Primary Antibody for IF, ELISA - ABIN1533739
Villard, Lossi, Cardoso, Proud, Chiaroni, Colleaux, Schwartz, Fontés: Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase. in Genomics 1997
Human Polyclonal ATRX Primary Antibody for FACS, WB - ABIN655910
Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010
Human Polyclonal ATRX Primary Antibody for ELISA, WB - ABIN1450956
McKay, Troelstra, van der Spek, Kanaar, Smit, Hagemeijer, Bootsma, Hoeijmakers: Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. in Genomics 1997
ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (show TP53 Antibodies) overexpression as compared to patients with wild-type ATRX
Loss of ATRX was highly associated with alternative lengthening of telomeres
For WHO grade II diffuse glioma, molecular classification using 1p/19qcodel, IDHmut, and ATRX loss more accurately predicts outcome and should be incorporated in the neuropathologic evaluation.
We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
Frequent ATRX mutations and aberrant ATRX gene expression in uterine leiomyosarcomas.
Daxx (show DAXX Antibodies) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS Antibodies) levels are low.
Loss of ATRX is associated with DNA methylation (show HELLS Antibodies) pattern of chromosome end and impacts biological behaviors of astrocytic tumors.
Data identify MDM2 (show MDM2 Antibodies) and ATRX as new regulators controlling geroconversion, the process by which quiescent cells become senescent.
ATRX interacts with ZNF274 (show ZNF274 Antibodies), TRIM28 (show TRIM28 Antibodies) and SETDB1 (show SETDB1 Antibodies) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (show ZNF274 Antibodies) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.
ATRX loss was the most likely mechanism of alternative telomere lengthening in liposarcoma and alternative telomere lengthening was a prognostic factor of poor outcome in dedifferentiated liposarcoma.
A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.
We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.
ATRX promotes the incorporation of histone H3.3 (show H3F3A Antibodies) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.
Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (show CISH Antibodies) along the X chromosome.
These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.
ATRX plays a direct role in facilitating DNA replication. Ablation of ATRX alone, although leading to a DNA damage response at telomeres, is not sufficient to trigger the alternative lengthening of telomere pathway in mouse embryonic stem cells.
The findings indicate that ATRX regulates gene expression at a subset of imprinted domains by maintaining a nucleosome configuration conducive to CTCF (show CTCF Antibodies) binding and to the maintenance of higher order chromatin structure.
Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly.
loss of ATRX increases DNA damage locally in the forebrain and anterior pituitary and causes tissue attrition and other systemic defects similar to those seen in aging
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
ATP-dependent helicase ATRX
, DNA dependent ATPase and helicase
, X-linked helicase II
, X-linked nuclear protein
, Zinc finger helicase
, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
, helicase 2, X-linked
, transcriptional regulator ATRX
, alpha thalassemia/mental retardation syndrome X-linked homolog
, helicase II
, HP1 alpha-interacting protein
, alpha thalassemia/mental retardation syndrome (X-linked)
, heterochromatin protein 2
, DNA repair and recombination protein RAD54-like
, RAD54 homolog