ATRX antibody

Catalog No. ABIN7861425

The Mouse Monoclonal anti-ATRX antibody is suitable to detect ATRX in samples from Human. It has been validated for IHC.

Quick Overview for ATRX antibody (ABIN7861425)

Target: ATRX (helicase 2, X-linked (ATRX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ATRX-7940

Product Details anti-ATRX Antibody

Purpose: ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody

Specificity: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 é 79oΩ to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with é 79oΩ thalassemia or ATRX syndrome

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human ATRX protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background:

Alpha thalassemia/mental retardation syndrome X linked homolog, ATP-dependent helicase ATRX, ATR2, ATRX, DNA-dependent ATPase and helicase, MRXHF1, RAD54, RAD54L, SFM1, SHS, Transcriptional regulator ATRX, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf-HX

adrenal|Human pancreas|kidney|ovary|prostate or stomach.

Molecular Weight: 280kDa

Gene ID: 546, 533526, 653797

UniProt: P46100