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ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ARHGAP21 Kits (3) and many more products for this protein.
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Gly1121Ser variant in ARHGAP21 gene found to be shared by all MP individuals in arger branch of family with nearly complete penetrance. ARHGAP21 protein strengthens cell-cell adhesions; may be regulated by BMPs influencing mandibular growth.
ARHGAP21 is a Rho-GAP (show ARHGAP36 Antibodies) involved in cell-cell junction remodeling that affects migration and EMT (show ITK Antibodies) through alpha-tubulin (show TUBA4A Antibodies) interaction and acetylation
Co-immunoprecipitations and in vitro SUMOylation confirmed ARHGAP21 specific modification by SUMO2/3 and mapped the SUMOylation site to ARHGAP21 lysine K1443.
silencing Cdc42 reduced influenza A virus replication, whereas silencing ARHGAP21 increased the virus replication.
Disruption of the beta-arrestin 1 (show ARRB1 Antibodies)/ARHGAP21 complex results in a more active ARHGAP21, leading to less efficient signaling via the angiotensin II type 1A receptor (show AGTR1a Antibodies) and, thereby, attenuation of stimulated stress fiber formation.
ARHGAP10 gene is highly expressed in muscle and brain, which are highly differentiated tissues. It supports the hypothesis that ARHGAP10 is important for cell differentiation
The ARHGAP10 protein is a novel Rho GTPase-activating protein (show STARD13 Antibodies) (Rho-GAP (show ARHGAP36 Antibodies)) that is recruited to Golgi membranes through binding to GTP (show AK3 Antibodies)-ARF1 (show ARF1 Antibodies).
The crystal structure of the activated GTP-bound form of ARF1 in a complex with the Arf-binding domain (ArfBD) of ARHGAP21 at 2.1 A resolution, is presented.
Data demonstrate that the RhoGTPase activating protein 21 (ARHGAP21) is expressed in the nuclear and perinuclear regions of several cell lines, and interacts with the C-terminal region of focal adhesion kinase.
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005
Rho-GTPase activating protein 10
, rho GTPase-activating protein 10
, rho GTPase-activating protein 21
, rho-type GTPase-activating protein 21