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The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. Additionally we are shipping serine/threonine Kinase 24 Antibodies (89) and serine/threonine Kinase 24 Kits (3) and many more products for this protein.
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CCM3 (show PDCD10 Proteins) signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
This study demonistrated that MST3 kinase phosphorylates TAO1 (show TAOK2 Proteins)/2 to enable Myosin Va (show MYO5A Proteins) function in promoting spine synapse development.
This review notes that in the SOK1 (show STK25 Proteins) and MST4 (show MST4 Proteins) germinal center kinase (show MAP4K2 Proteins) III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
These data provide molecular understanding of the mechanism by which MO25 (show CAB39 Proteins) isoforms regulates the activity of STE20 family protein kinases.
results show that a STRADalpha-rac1-PAK1 (show PAK1 Proteins) pathway regulates cell polarity and invasion in LKB1 (show STK11 Proteins)-null cells. It also suggests that while the function of LKB1 (show STK11 Proteins) and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
mechanism of regulation of MST3
Striatin (show STRN Proteins) orchestrates the regulation of Mst3 by PP2A (show PPP2R4 Proteins).
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
Proteolytic activation of Mst3 by caspases.
Mst3 contains signals which may cooperate to control the subcellular distribution of Mst3.
Mst3 phosphorylates RhoA (show RHOA Proteins) at Ser26, thereby negatively regulating the activity of RhoA (show RHOA Proteins) in neurons.
STK24 appears to suppress exocytosis by interacting and competing with UNC13D (show UNC13D Proteins) C2B domain for lipid binding, whereas CCM3 (show PDCD10 Proteins) has dual roles in exocytosis regulation.
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000
serine/threonine kinase 24 (STE20 homolog, yeast)
, serine/threonine-protein kinase 24
, STE20-like kinase 3
, STE20-like kinase MST3
, mammalian STE20-like protein kinase 3
, sterile 20-like kinase 3
, mammalian sterile twenty 3 kinase