serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 Proteins (SERPINA1)

The protein encoded by SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Additionally we are shipping SERPINA1 Antibodies (433) and SERPINA1 Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPINA1 20701 P22599
SERPINA1 5265 P01009
SERPINA1 24648 P17475
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Top SERPINA1 Proteins at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_HEK-293 Cells Human His tag Human Serpin A1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 11 Days
$308.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Cells Human His tag 10 μg Log in to see 2 to 3 Days
$235.00
Details
HOST_Human Human Un-conjugated 1 mg Log in to see 2 to 3 Days
$85.00
Details
HOST_Human Cells Rat His tag 50 μg Log in to see 20 to 21 Days
$547.80
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$548.63
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details

SERPINA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , , , , ,
, , , ,
Rat (Rattus) , ,

Top referenced SERPINA1 Proteins

  1. Human SERPINA1 Protein expressed in Human Cells - ABIN2002549 : Perlmutter, Daniels, Auerbach, De Schryver-Kecskemeti, Winter, Alpers: The alpha 1-antitrypsin gene is expressed in a human intestinal epithelial cell line. in The Journal of biological chemistry 1989 (PubMed)
    Show all 3 references for 2002549

  2. Human SERPINA1 Protein expressed in HEK-293 Cells - ABIN2181744 : Niemann, Narkates, Miller: Isolation and serine protease inhibitory activity of the 44-residue, C-terminal fragment of alpha 1-antitrypsin from human placenta. in Matrix (Stuttgart, Germany) 1992 (PubMed)
    Show all 2 references for 2181744

  3. Human SERPINA1 Protein expressed in HEK-293 Cells - ABIN2714593 : Yao, Guihard, Blazquez-Medela, Guo, Moon, Jumabay, Boström, Yao: Serine Protease Activation Essential for Endothelial-Mesenchymal Transition in Vascular Calcification. in Circulation research 2015 (PubMed)

More Proteins for serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) Interaction Partners

Horse (Equine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Although circulating nucleosomes and elastase - alpha 1-antitrypsin complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (show SLC44A2 Proteins) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.

Chimpanzee serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. The mechanism underlying the alpha(1)PI deficiency that attends HIV-1 infection, was investigated.

Mouse (Murine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Loss of alpha 1-Antitrypsin is associated with emphysema.

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. high A1AT expression correlated with increased tumor stage, elevated p53 (show TP53 Proteins) staining and shorter overall survival in lung adenocarcinoma patients.

  2. These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway.

  3. AAT (show SERPINA1A Proteins) heterozygous status in rheumatoid arthritis is strongly associated with positive anti-citrullinated peptide autoantibodies and may define a distinct subset of patients with increased disease severity.

  4. Report alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide.

  5. SNP rs8004738 of SERPINA1 gene significantly interacted with smoking status and was associated with a higher risk for COPD (show ARCN1 Proteins) in the Chinese population.

  6. tissue specific expression and regulation of short transcripts of SERPINA1 gene and the presence of C-terminal peptides in supernatants from activated neutrophils

  7. SERPINA1 variants are associated with ANCA-associated vasculitis risk.

  8. Report incorporation of the Mmalton allele-specific genotyping assay in the diagnostic algorithm of alpha-1-antitrypsin deficiency.

  9. The expression and intracellular accumulation of mutated Z-alpha-1 antitrypsin (the most common mutation) compromises macrophage function and contributes to emphysema development. Macrophages from individuals with Z-AAT (show SERPINA1A Proteins) have more proteolytic activity on ECM (show MMRN1 Proteins) than normal. This abnormal activity is not abrogated by exogenous AAT (show SERPINA1A Proteins) and may be the result of cellular dysfunction induced by intracellular accumulation of Z-AAT (show SERPINA1A Proteins).

  10. hAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr (show FAS Proteins) lupus model

Cow (Bovine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Comparisons of the expression patterns of cattle fetuses and their dams show that the PI gene is biallelically expressed in fetuses and predominantly monoallelically expressed in the dams.

SERPINA1 Protein Profile

Protein Summary

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SERPINA1

  • SH2B adaptor protein 2 (Sh2b2)
  • alpha-1-antitrypsin (SPI2)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (serpina1)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1)
  • alpha-1-antitrypsin (LOC100328621)
  • serine (or cysteine) preptidase inhibitor, clade A, member 1B (Serpina1b)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (Serpina1)
  • A1A protein
  • A1AT protein
  • AAT protein
  • alpha-1-PI protein
  • alpha1AT protein
  • Aps protein
  • D12Ucla2 protein
  • Dom2 protein
  • MGC64429 protein
  • Pi protein
  • PI1 protein
  • PI2 protein
  • PRO2275 protein
  • SERPINA1 protein
  • serpina1d protein
  • Spi1 protein
  • Spi1-2 protein

Protein level used designations for SERPINA1

alpha-1-antiproteinase S , alpha-1-antitrypsin , alpha-1-proteinase inhibitor , alpha-1-antiproteinase 2 , alpha-1-antitrypsin 2 , alpha-1-proteinase inhibitor 2 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , serine (or cysteine) proteinase inhibitor, clade A, member 1d , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , alpha-1 protease inhibitor , alpha-1-antiproteinase , serpin A1 , AAT , alpha-1 protease inhibitor 2 , alpha-1-antitrypsin 1-2 , serine (or cysteine) proteinase inhibitor, clade A, member 1b , serine protease inhibitor 1-2 , serine protease inhibitor A1b , serpin A1b , alpha-1-antitrypsin null , protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin , serine (or cysteine) proteinase inhibitor, clade A, member 1 , alpha-1-antitrypsin (protease inhibitor) , alpha-1-protease inhibitor , serine protease inhibitor alpha 1 , alpha 1 antitrypsin , protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1) , serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1 , serine proteinase inhibitor, clade A, member 1 , alpha-1 antitrypsin , protease inhibitor 1 , Alpha-1 protease inhibitor

GENE ID SPECIES
100379265 Cavia porcellus
100065158 Equus caballus
379963 Xenopus laevis
423434 Gallus gallus
467541 Pan troglodytes
701361 Macaca mulatta
100145012 Xenopus (Silurana) tropicalis
100171544 Pongo abelii
100328621 Oryctolagus cuniculus
20701 Mus musculus
5265 Homo sapiens
24648 Rattus norvegicus
480422 Canis lupus familiaris
397688 Sus scrofa
280699 Bos taurus
443388 Ovis aries
101841330 Mesocricetus auratus
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