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The protein encoded by SERPINB1 is a member of the serpin family of proteinase inhibitors. Additionally we are shipping serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 Kits (15) and serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 Proteins (13) and many more products for this protein.
Showing 10 out of 105 products:
Human Polyclonal SERPINB1 Primary Antibody for EIA, WB - ABIN954744
Wang, Fu, Xie, Wang, Chu, Wang, Shen, Wang, Wang, Sun, Lei, Yang, Wu, Foo, Liu, Jin, Huang: Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. in Journal of human genetics 2010
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our findings reveal a novel function of serpinB1 in limiting untoward expansion of lymphocytes with a Th17 phenotype.
SerpinB1 is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G (show CTSG Antibodies) activity.
Expression of Leukocyte elastase inhibitor in the ovary and oviduct of infected VDR (show CYP27B1 Antibodies)(+/+) mice was greater than that of infected VDR (show CYP27B1 Antibodies)(-/-) mice.
Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 (show SERPINB4 Antibodies) and SERPINB9 (show SERPINB9 Antibodies) for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors.
Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC (show HLAE Antibodies)-I and CD1d (show CD1D Antibodies) expression. Intriguingly, expression of SERPINB9 (show SERPINB9 Antibodies), SERPINB1, and SERPINB4 (show SERPINB4 Antibodies) is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors
Data suggest that serine protease inhibitor (SERPIN) B1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of matrix metalloproteinase-2 and the activation of focal adhesion kinase.
Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma.
Apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death.
Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH (show GZMH Antibodies). SERPINB1 overexpression suppresses GzmH (show GZMH Antibodies)- or LAK (show ARL4C Antibodies) cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH (show GZMH Antibodies) for the suicide inhibition.
In the resting state during human neutrophil extracellar trap generation, SerpinB1 is exclusively in the cytoplasm, consistent with the current understanding of clade B serpins, and it may migrate and regulate events in the cell nucleus.
These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease.
serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses.
The findings define an innate role for SerpinB1 in cystic fibrosis (show S100A8 Antibodies) airways.
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.
serpin peptidase inhibitor, clade B (ovalbumin), member 1
, protease inhibitor 2, monocyte/neutrophil derived
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1
, Leukocyte elastase inhibitor
, leukocyte elastase inhibitor-like
, leukocyte elastase inhibitor A
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1a
, serine (or cysteine) proteinase inhibitor, clade B, member 1a
, serine protease inhibitor EIA
, serpin B1a
, leukocyte elastase inhibitor
, peptidase inhibitor 2
, protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived
, serpin B1
, leukocyte elastase inhibitor A-like protein
, serpin peptidase inhibitor, clade B (ovalbumin), member 1 tv1