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Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity).. Additionally we are shipping TRIT1 Antibodies (16) and many more products for this protein.
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We show that dysfunctional TRIT1 results in decreased levels of select mitochondrial proteins. Our findings confirm the TRIT1 disease association and advance the phenotypic and molecular understanding of this disorder.
characterize TRIT1 as a novel human amyloid fiber forming protein. We discuss these data in light of TRIT1's functional roles and possible implications for disease
patient cells bearing the p.Arg323Gln TRIT1 mutation are severely deficient in i6A37 in both cytosolic and mitochondrial tRNAs
In light of this additional nuclear role for Mod5 we discuss the proposed role of the human homologue of Mod5, TRIT1, as a tumor suppressor protein (show TP53 Proteins).[review]
TRIT1 may control the levels of some tRNAs as well as their specific activity.
One TRIT1 haplotype, CCGT, was associated with lymph node metastasis.
The rare allele of TRIT1 Phe202Leu SNP was approximately seven-fold more frequent in Asian than in Caucasian subjects and three additional SNPs in the TRIT1 gene showed ethnic differences in allelic frequencies
Knockdown of Trit1 reduces expression of selenoproteins.
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity).
tRNA isopentenyltransferase 1
, tRNA dimethylallyltransferase, mitochondrial
, tRNA dimethylallyltransferase, mitochondrial-like
, IPP transferase
, isopentenyl-diphosphate:tRNA isopentenyltransferase
, tRNA isopentenylpyrophosphate transferase
, tRNA isopentenyltransferase, mitochondrial