Piceatannol
1 image
-
- Application
- Activation (Act)
- Characteristics
-
Activator of SIRT1
Inhibits NF-kB activation
Induces apoptosis
-
-
- Restrictions
- For Research Use only
-
- Storage
- 4 °C
-
- Background
- Activator of human deacetylase SIRT1. Anti-inflammatory, immunomodulatory and antiproliferative agent that inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-kB activation and gene expression. Piceatannol is a resveratrol analog formed by the cytochrome P450-catalyzed hydroxylation of resveratrol. Piceatannol exhibits potent anticancer properties by inducing apoptosis in BJAB Burkitt-like lymphoma cells with an ED50 value of 25 µM. Piceatannol also exhibits anti-proliferative and anti-inflammatory effects by inhibiting the activity of a wide range of tyrosine and serine/threonine protein kinases and suppressing NF-kB activation through inhibition of IkBa kinase.
- CAS-No
- 10083-24-6
-
You are here:
