Chlorotoxin
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- Target
- Chlorotoxin
- Application
- Blocking Reagent (BR)
- Purpose
- Chlorotoxin is supposed to inhibit chloride channels
- Sequence
- Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2Disulfide bonds between Cys2-Cys19, Cys5-Cys28,Cys16-Cys33 and Cys20-Cys35
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- Restrictions
- For Research Use only
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- Target
- Chlorotoxin
- Background
- Chlorotoxin is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin binds to Cl-channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding.
- Molecular Weight
- 3995.8 Da
- CAS-No
- 163515-35-3
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