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anti-Mouse (Murine) Angiotensin I Converting Enzyme 2 Antibodies:
anti-Human Angiotensin I Converting Enzyme 2 Antibodies:
anti-Rat (Rattus) Angiotensin I Converting Enzyme 2 Antibodies:
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Human Monoclonal Angiotensin I Converting Enzyme 2 Primary Antibody for WB - ABIN1882190
Itoyama, Keicho, Hijikata, Quy, Phi, Long, Ha, Ban, Matsushita, Yanai, Kirikae, Kirikae, Kuratsuji, Sasazuki: Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population. in American journal of medical genetics. Part A 2005
Show all 3 Pubmed References
Human Polyclonal Angiotensin I Converting Enzyme 2 Primary Antibody for IHC, IHC (p) - ABIN4277591
Lee, Nam, Park, Kim, Lafleur, Aburatani, Yang, Kim, Goldenring: Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. in Gastroenterology 2010
Show all 2 Pubmed References
Human Polyclonal Angiotensin I Converting Enzyme 2 Primary Antibody for ELISA, WB - ABIN1169446
Beniac, deVarennes, Andonov, He, Booth: Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. in PLoS ONE 2007
Human Monoclonal Angiotensin I Converting Enzyme 2 Primary Antibody for FACS, ELISA - ABIN1169449
Zulli, Rai, Buxton, Burrell, Hare: Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques. in Experimental physiology 2008
Human Polyclonal Angiotensin I Converting Enzyme 2 Primary Antibody for FACS, IF (p) - ABIN730798
Raffai, Khang, Vanhoutte: Angiotensin-(1-7) augments endothelium-dependent relaxations of porcine coronary arteries to bradykinin by inhibiting angiotensin-converting enzyme 1. in Journal of cardiovascular pharmacology 2014
Cow (Bovine) Polyclonal Angiotensin I Converting Enzyme 2 Primary Antibody for IHC, WB - ABIN2774060
Haga, Yamamoto, Nakai-Murakami, Osawa, Tokunaga, Sata, Yamamoto, Sasazuki, Ishizaka: Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 Pubmed References
Human Polyclonal Angiotensin I Converting Enzyme 2 Primary Antibody for ELISA, ICC - ABIN4277590
Wang, Liang, Leung: The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. in PLoS ONE 2015
sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2.
Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas (show MAS1 Antibodies) receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 (show HMGB1 Antibodies) and proinflammatory cytokine expression.
ACE2 regulates vascular function by modulating nitric oxide release.
MAS (show MAS1 Antibodies) receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS (show MAS1 Antibodies) axis functionality
ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin (show INS Antibodies) resistance.
a Mas (show MAS1 Antibodies) receptor-mediated mechanism may stimulate pancreatic cell development
ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE Antibodies)-mutant mice through modulation of the nephrin (show NPHS1 Antibodies), NOX4 (show NOX4 Antibodies) and TNF-alpha (show TNF Antibodies)-TNFRSF1A (show TNFRSF1A Antibodies) signaling.
Hydronephrosis led to an increase of ACE (show ACE Antibodies) level and a decrease of ACE2 and Mas (show MAS1 Antibodies) receptor in the heart.
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
In a pig model of acute pulmonary embolism leading to cardiac arrest, captopril infusion was associated with less mean right ventricular pressure overload after resuscitation, compared with saline infusion. The reduction in systemic and pulmonary vascular resistance associated with captopril may be by inhibiting the ACE (show ACE Antibodies)-Ang II (show AGT Antibodies)-AT1R (show AGTR1 Antibodies) axis and activating the ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) axis.
This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.
activation of the central rennin-angiotensin system in animals with chronic heart failure involves an imbalance of ACE (show ACE Antibodies) and ACE2 in regions of the brain that regulate autonomic function.
Overexpression of ACE2 inhibited atherosclerotic plaque inflammation response in hypercholesterolemic rabbits.
The findings of this study indicate that ACE-2 activity is reduced in AD and is an important regulator of the central classical ACE-1 (show ACE Antibodies)/Ang II (show AGT Antibodies)/AT1R (show AGTR1 Antibodies) axis of renin (show REN Antibodies)-angiotensin system, and also that dysregulation of this pathway likely plays a significant role in the pathogenesis of Alzheimer's disease.
Overexpression of ACE2 ameliorates Abeta (show APP Antibodies)-induced inflammatory response by activating the ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) axis in human RPE (show RPE Antibodies) cells.
Although further studies are required to determine how clusterin (show CLU Antibodies) suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin (show CLU Antibodies) plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles.
The ACE2 G8790A polymorphism in type 2 diabetes mellitus patients was correlated with cerebral stroke, and the A allele might be a risk factor of type 2 diabetes mellitus combined with cerebral stroke.
ollectrin, an ACE2 homolog with no catalytic activity, regulates blood pressure through an NO-dependent mechanism. Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) receptor axis activation on hypertension and vascular injury.
The potential contribution of the ACE2 to cardiovascular disease progression was addressed.
Serum ACE2 activity was significantly lower in acute ischemic stroke as compared to both control and stroke-alert patients, followed by an increase to control levels at three days.
Here, we review the role and effects of ACE2, ACE2 activators, Ang-(1 (show ANGPT1 Antibodies)-7) and synthetic Mas (show MAS1 Antibodies) receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (show ACE Antibodies)-Ang II (show AGT Antibodies)-AT1 (show AGTR1 Antibodies) axis.
ACE2 overexpression inhibited cell growth.
Downregulation of ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/Snail1 (show SNAI1 Antibodies) pathways.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
angiotensin I converting enzyme 2
, angiotensin-converting enzyme 2
, ACE-related carboxypeptidase
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
, angiotensin-converting enzyme homolog
, metalloprotease MPROT15
, peptidyl-dipeptidase A
, anigotensin-converting enzyme-related carboxypeptidase
, renal angiotensin-converting enzyme 2