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The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
Downregulation of ACE2 (show ACE2 Proteins)/Ang-(1 (show ANGPT1 Proteins)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 Proteins)/NF-kappaB (show NFKB1 Proteins)/Snail1 (show SNAI1 Proteins) pathways.
These results indicated that angiotensin-(1-7)/ACE2 (show ACE2 Proteins)/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM (show CALM1 Proteins) signaling pathway.
Ang-(1 (show ANGPT1 Proteins)-7) downregulated AT1R (show AGTR1 Proteins) mRNA, upregulated mRNA levels of Ang II (show AGT Proteins) type 2 receptor (AT2R (show AGTR2 Proteins)) and Mas receptor (MasR) and p38-MAPK (show MAPK14 Proteins) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (show ACE2 Proteins)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (show ACE2 Proteins)/Ang-(1 (show ANGPT1 Proteins)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (show MAPK1 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (show PIPOX Proteins) [SRY (show SRY Proteins) (sex-determining region on the Y chromosome) box] proteins SRY (show SRY Proteins), SOX2 (show SOX2 Proteins), SOX3 (show SOX3 Proteins) and SOX14 (show SOX14 Proteins), of which SRY (show SRY Proteins) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor (show AGTRAP Proteins) signaling pathways.
Ang-(1 (show ANGPT1 Proteins)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (show AGT Proteins)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (show ACE2 Proteins)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (show TLR4 Proteins)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (show TLR4 Proteins).
a Mas receptor-mediated mechanism may stimulate pancreatic cell development
Hydronephrosis led to an increase of ACE (show ACE Proteins) level and a decrease of ACE2 (show ACE2 Proteins) and Mas receptor in the heart.
TGF-beta (show TGFB1 Proteins) inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes in animal model of muscular distrophy.
Deletion of the MasR causes marked increase in the aortic intima:media ratio, which is not due to generalized cellular proliferation.
The complete mouse Mas gene structure and organization.
Participation of AT1 (show SLC33A1 Proteins) and Mas receptors in the modulation of inflammatory pain.
oncogene\; may be involved in function or development of neural tissues
, proto-oncogene Mas
, MAS proto-oncogene
, angiotensin-(1-7) receptor