Browse our anti-AIM2 (AIM2) Antibodies

Full name:
anti-Absent in Melanoma 2 Antibodies (AIM2)
On are 192 Absent in Melanoma 2 (AIM2) Antibodies from 26 different suppliers available. Additionally we are shipping AIM2 Kits (14) and AIM2 Proteins (6) and many more products for this protein. A total of 229 AIM2 products are currently listed.
AIM2, Gm1313, Ifi210, PYHIN4
list all antibodies Gene Name GeneID UniProt
AIM2 9447 O14862
AIM2 383619 Q91VJ1
AIM2 304987  

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anti-Human AIM2 Antibodies:

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Top referenced anti-AIM2 Antibodies

  1. Human Polyclonal AIM2 Primary Antibody for EIA, FACS - ABIN950314 : Patsos, Germann, Gebert, Dihlmann: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. in International journal of cancer. Journal international du cancer 2010 (PubMed)
    Show all 6 references for 950314

  2. Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882191 : Chen, Ou-Yang, Hung, Liu, Wang, Wang, Hou, Hortobagyi, Hung: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. in Molecular cancer therapeutics 2006 (PubMed)
    Show all 5 references for 1882191

  3. Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882206 : DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997 (PubMed)
    Show all 5 references for 1882206

  4. Human Polyclonal AIM2 Primary Antibody for FACS, IF - ABIN653833 : Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. in Nature 2009 (PubMed)
    Show all 4 references for 653833

  5. Human Monoclonal AIM2 Primary Antibody for ICC, WB - ABIN1169341 : Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 3 references for 1169341

  6. Human Polyclonal AIM2 Primary Antibody for ELISA, IHC - ABIN4278860 : Choubey, Duan, Dickerson, Ponomareva, Panchanathan, Shen, Srivastava: Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010 (PubMed)
    Show all 2 references for 4278860

  7. Human Polyclonal AIM2 Primary Antibody for ELISA, WB - ABIN1534265 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for 1534265

  8. Human Polyclonal AIM2 Primary Antibody for EIA, IHC (p) - ABIN569662 : Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. in Nature 2009 (PubMed)

  9. Horse (Equine) Polyclonal AIM2 Primary Antibody for WB - ABIN2784209 : Woerner, Kloor, Schwitalle, Youmans, Doeberitz, Gebert, Dihlmann: The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. in Genes, chromosomes & cancer 2007 (PubMed)

More Antibodies against AIM2 Interaction Partners

Human Absent in Melanoma 2 (AIM2) interaction partners

  1. The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.

  2. The extent of NLRC3 (show NLRC3 Antibodies) and AIM2 gene reduction was correlated with cancer progression.

  3. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  4. A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (show IFI16 Antibodies) in active inflammatory bowel disease versus controls was found.

  5. Lung tumor-associated plasmacytoid dendritic cells (pDCs) are responsive to the activation of AIM2 that promotes calcium efflux and reactive oxygen species from mitochondria, leading to calpain activation and high levels of IL-1alpha.

  6. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Antibodies), NLRC4 (show NLRC4 Antibodies) and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Antibodies) speck

  7. pyrin (show MEFV Antibodies) domain drives both filament formation and dsDNA binding

  8. activation of the AIM2 inflammasome did not require a priming signal in ascitic fluid-derived macrophages, demonstrating the preactivated state of the inflammasome in these cells.

  9. These results suggest that AIM2 expressed in human dental pulp plays an important role in the immune defense by activating the inflammasome signaling pathway.

  10. The comparison shows mouse AIM2 PYD domain adopts a unique alpha2-alpha3 helix conformation distinct from its human homologues, but similar to the pyrin (show MEFV Antibodies) domain of human NLRP10/PYNOD (show NLRP10 Antibodies), which belongs to another family.

Mouse (Murine) Absent in Melanoma 2 (AIM2) interaction partners

  1. These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (show IL18 Antibodies)/IL-22BP (show IL22RA2 Antibodies)/IL-22 (show IL22 Antibodies) and STAT3 (show STAT3 Antibodies) pathway

  2. AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.

  3. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  4. in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 Antibodies)-dependent cell death.

  5. A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.

  6. AIM2 inflammsome is functionally redundant in the inflammasomemediated caspase-1 (show CASP1 Antibodies) activation and IL-1beta (show IL1B Antibodies) production during P. aeruginosa infection.

  7. Mice lacking both AIM2 and NLRP3 (show NLRP3 Antibodies) fail to confine Aspergillus hyphae to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.

  8. AIM2 reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2(-/-) mice

  9. For the first time, this paper demonstrated that miR (show MLXIP Antibodies)-223 acted to inhibit IL-1beta (show IL1B Antibodies) production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF (show GTF2A1L Antibodies). Thus, it played an important role in the pathogenesis of ALF (show GTF2A1L Antibodies).

  10. Study found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact in Aim2-deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation.

AIM2 Antigen Profile

Antigen Summary

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

Alternative names and synonyms associated with AIM2

  • absent in melanoma 2 (AIM2) antibody
  • absent in melanoma 2 (Aim2) antibody
  • AIM2 antibody
  • Gm1313 antibody
  • Ifi210 antibody
  • PYHIN4 antibody

Protein level used designations for AIM2

absent in melanoma 2 , interferon-inducible protein AIM2-like , interferon-inducible protein AIM2 , ifi-210 , interferon-inducible protein 210 , interferon-inducible protein p210

457425 Pan troglodytes
100459446 Pongo abelii
719260 Macaca mulatta
9447 Homo sapiens
383619 Mus musculus
304987 Rattus norvegicus
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