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Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta (show PKCd ELISA Kits), which stimulates PKCgamma (show PRKCG ELISA Kits), resulting in translocation of phosphorylated p47(phox).
HCK represents a novel target for therapeutic development in MYD88 (show MYD88 ELISA Kits)-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88 (show MYD88 ELISA Kits).
High HCK levels correlate with reduced survival of colorectal cancer patients and is associated with activated macrophages gene signature.
three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large cost difference (49.31), containing three ring aromatic and one hydrophobic aliphatic feature
we provide evidence for involvement of HCK and FGR (show FGR ELISA Kits) in FCRL4 (show FCRL4 ELISA Kits)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 ELISA Kits) molecule.
Interaction with the Src (show SRC ELISA Kits) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.
Data indicate that combined treatment using SFK (LYN (show LYN ELISA Kits), HCK, or FGR (show FGR ELISA Kits)) and c-KIT (show KIT ELISA Kits) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 ELISA Kits) activity and enhancing targeting of acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) stem cells.
The SRC (show SRC ELISA Kits) family tyrosine kinase (show TXK ELISA Kits) HCK and the ETS (show ETS1 ELISA Kits) family transcription factors SPIB (show SPIB ELISA Kits) and EHF (show EHF ELISA Kits) regulate transcytosis across a human follicle-associated epithelium model.
This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.
the Hck, Fgr (show FGR ELISA Kits) and Lyn (show LYN ELISA Kits) kinases are also necessary for amastigote uptake by macrophages. Src (show SRC ELISA Kits)-mediated Arg activation is required for efficient uptake.
Hematopoietic Hck promotes tumorigenesis.
Data suggest that Hck is a key mediator of renal fibrosis
Data indicate that Src (show SRC ELISA Kits)-Family Kinases Hck and Fgr (show FGR ELISA Kits) regulate cytokine secretion by macrophages.
Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
The Src (show SRC ELISA Kits) family kinases Hck, Fgr (show FGR ELISA Kits), and Lyn (show LYN ELISA Kits) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
tyrosine phosphorylation of WASP by Hck is required for proper macrophage functions
Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.
Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (show FGR ELISA Kits)/Lyn (show LYN ELISA Kits)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Taken together, PKR (show EIF2AK2 ELISA Kits) and Hck were critical for DON-induced ribosomal recruitment of p38 (show CRK ELISA Kits), its subsequent phosphorylation, and, ultimately, p38 (show CRK ELISA Kits)-driven proinflammatory cytokine expression.
A truncated, mRNA-encoded src-related tyrosine kinase (show FRK ELISA Kits) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.
the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
hemopoietic cell kinase
, non-receptor protein tyrosine kinase laloo
, tyrosine-protein kinase HCK-like
, hematopoietic cell kinase
, tyrosine-protein kinase HCK
, B cell/myeloid kinase
, B-cell/myeloid kinase
, hemopoietic cell tyrosine kinase