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Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
Male mouse and marmoset proximal urethral smooth muscle shows strong alpha1A- adrenoceptor-induced contractions and abundant alpha1A-adrenoceptor expression, whereas alpha1A-adrenoceptor-mediated mechanisms are much less important in females.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta (show PKCd Proteins)-mediated GLUT (show SLC1A3 Proteins) translocation that may be specific to the alpha(1A)-AR subtype.
Data identify a novel, "inside-out" nuclear a1A-subtype/PKCd/cTnI-signaling pathway that regulates contractile function in adult cardiac myocytes.
Male contraception via simultaneous knockout of alpha1A (show CACNA1A Proteins)-adrenoceptors and P2X1 (show P2RX1 Proteins)-purinoceptors in mice.
We have provided the first evidence for specific heteromerization between the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor (show CXCR4 Proteins) 2 (CXCR2 (show CXCR2 Proteins)) in live cells.
sustained activation of IL-1 (show IL1A Proteins) signaling....affects the expression of the ARalpha(1A) subtype..and that modification of adrenergic signaling by the IL-1 (show IL1A Proteins) system may ultimately cause significant psychiatric abnormalities such as depression
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1 (show WNK1 Proteins), SPAK (show STK39 Proteins), and NKCC1 (show SLC12A2 Proteins) and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
Activation of the adrenergic receptor alpha 1a subtype enhances learning and memory and has antidepressant and antianxiety effects.
result is consistent with coimmunoprecipitation experiments from thoracodorsal resistance arteries, which suggested an association between Pannexin1 (show PANX1 Proteins) and alpha1D-adrenergic receptor
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (show NR3C1 Proteins) with neonatal glucose and lipid metabolism.
modeling of full-length alpha(1a) adrenergic receptor due to its biological role and significant implications in pharmacological treatment of benign prostate hyperplasia
Stimulation of transfected bovine alpha1A-AR promotes cell cycle arrest, hypertrophy and differentiation of fibroblasts into smooth muscle-like cells and expression of negative cell cycle regulators by a mechanism independent of cAMP/PKA signaling
A mutation of rs2322333, located in the intronic and 3'UTR part of the gene ADRA1A in chromosome 8, has a probability of being deleterious the abolition of ELAV-like protein 1 (ELAVL1 (show ELAVL1 Proteins)) binding site rs2695260. SNP rs2322333 in adrenergic receptor alpha1 (ADRA1A) was higher in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis compared with healthy controls
Immunoreactivity for ADRA1A was densely distributed in vascular smooth muscle of nasal turbinates.
alpha1A-adrenoceptor subtypes predominantly contributed to human IAS contraction
Data are presented that indicate that Iso represents a novel type of alpha1A-AR partial agonist with signaling bias toward MAPK/ERK (show MAPK1 Proteins) signaling cascade that is likely independent of coupling to Galphaq (show GNAQ Proteins).
alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1 (show TGFB1 Proteins), IGF-1 (show IGF1 Proteins), hyaluronan and PIP (show PIP Proteins) production in human skin fibroblasts.
Data suggested ADRA1A Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope; ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population
heteromeric receptor complexes between alpha1A-AR and CXCR4 (show CXCR4 Proteins) and between alpha1B-AR and CXCR4 (show CXCR4 Proteins) are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
The ADRA1A mutant triggers two distinct EGFR (show EGFR Proteins) transactivation-dependent signaling pathways: 1) constitutive Gq-independent beta-arrestin-1 (show ARRB1 Proteins)/Src (show SRC Proteins)/MMP/EGFR (show EGFR Proteins)/ERK (show EPHB2 Proteins)-dependent hyperproliferation and 2) agonist-induced Gq- and EGFR (show EGFR Proteins)/STAT (show STAT1 Proteins)-dependent hypertrophy.
The alpha-AR-induced mydriasis in mice is mediated mainly by the alphaA-AR, with a smaller contribution of the alphaB-AR, matching the relative abundance of these subtypes at the mRNA level.
Adrenergic alpha1A receptor subtypes transactivate epidermal growth factor (show EGF Proteins) receptors.
Results suggest that contraction of circular smooth muscle from the pig internal anal sphincter is mediated via alpha1A/L-adrenoceptors.
Two distinct adrenoceptor phenotypes (alpha1A and alpha1L) with high and moderate affinities for prazosin are co-expressed in the iris of albino rabbits.
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.
G protein coupled receptor
, adrenergic, alpha-1A-, receptor variant 1
, adrenergic, alpha-1A-, receptor variant 11
, adrenergic, alpha-1A-, receptor variant 3
, adrenergic, alpha-1A-, receptor variant 5
, adrenergic, alpha-1A-, receptor variant 8
, alpha-1A adrenergic receptor
, alpha-1A adrenoceptor
, alpha-1A adrenoreceptor
, alpha-1C adrenergic receptor
, adrenergic alpha 1c receptor
, adrenergic receptor alpha 1c subtype
, adrenergic receptor, alpha 1a
, adrenergic receptor, alpha 1c
, adrenergic, alpha-1A-, receptor
, alpha 1A-adrenoceptor
, alpha 1A-adrenoreceptor
, alpha 1C-adrenergic receptor
, alpha 1a-adrenoceptor
, alpha-1A-adrenergic receptor
, adrenergic receptor alpha-1A