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Browse our PRKAA2 Proteins (PRKAA2)

Full name:
Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit Proteins (PRKAA2)
On www.antibodies-online.com are 9 Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA2 Antibodies (236) and PRKAA2 Kits (11) and many more products for this protein. A total of 267 PRKAA2 products are currently listed.
Synonyms:
2310008I11Rik, A830082D05, Ampk, AMPK2, AMPKA2, AMPKalpha2, PRKAA, prkaa1, PRKAA2
list all proteins Gene Name GeneID UniProt
PRKAA2 5563 P54646
Rat PRKAA2 PRKAA2 78975 Q09137
PRKAA2 108079 Q8BRK8

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PRKAA2 Proteins (PRKAA2) by Origin

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More Proteins for PRKAA2 Interaction Partners

Human Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. AMPK (show PRKAA1 Proteins) phosphorylation of cortactin (show CTTN Proteins) followed by SIRT1 (show SIRT1 Proteins) deacetylation modulates the interaction of cortactin (show CTTN Proteins) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Proteins)/SIRT1 (show SIRT1 Proteins) coregulated cortactin (show CTTN Proteins)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Proteins) subcellular translocation/activation and is atheroprotective.

  2. Data suggest that the AMPK (show PRKAA1 Proteins)-TBC1D4 (show TBC1D4 Proteins) signaling axis is likely mediating the improved muscle insulin (show INS Proteins) sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK (show PRKAA1 Proteins) in skeletal muscle.

  3. inactivation of AMPKalpha2, but not AMPKalpha1 (show PRKAA1 Proteins), abrogates the tumor attenuation caused by UBE2O (show UBE2O Proteins) loss.

  4. Our findings demonstrate that the AMPKalpha2 catalytic subunit in Kiss1 (show KISS1 Proteins) cells is dispensable for body weight and reproductive function in mice but is necessary for the reproductive adaptations to conditions of acute metabolic distress.

  5. Binding of miR (show MLXIP Proteins)-27a to the 3'-UTR of the AMPKalpha2 gene was required to increase the sensitivity of breast cancer cells to metformin.

  6. human cells were infected with lentiviruses expressing shRNA targeting both alpha1 and alpha2 AMPK (show PRKAA1 Proteins) subunits. AMPK (show PRKAA1 Proteins) activation inhibits Gli1 (show GLI1 Proteins)-driven proliferation and that this effect is linked to Ser408 phosphorylation, which represents a key metabolic checkpoint for Hh signaling.

  7. These data are in accordance with R6 binding directly to AMPKbeta2 when both proteins detach from the diminishing glycogen (show GYS1 Proteins) particle, which is simultaneous with increased AMPKbeta2 Thr (show TRH Proteins)-148 autophosphorylation.

  8. p-AMPKalpha (show GRK4 Proteins) was associated with cervical carcinogenesis, and high expression of AMPKalpha2 was correlated with better disease-free survival in patients with early-stage cervical cancer

  9. AMPK-alpha-2 binds to ER-alpha (show ESR1 Proteins), as well as ER-beta (show ESR2 Proteins).

  10. Data show that activated AMP-activated protein kinase (AMPK) limits retinal pigment epithelial cells (RPE (show RPE Proteins)) phagocytic activity by abolishing retinal photoreceptor cell outer segment (POS)-induced activation of c-mer proto-oncogene tyrosine kinase (MerTK (show MERTK Proteins)).

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).

  2. The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported.

  3. These data show that the AMPK (show PRKAA1 Proteins) activator AICAR (show ATIC Proteins) is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK (show PRKAA1 Proteins) [AMP-activated protein kinase alpha (show PAK1 Proteins) 1 subunit].

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. we used the Cre-loxP system to knock down AMPKalpha2 expression in renal epithelial cells. Combining this approach with the systemic deletion of AMPKalpha1 (show PRKAA1 Proteins) we achieved reduced renal AMPK (show PRKAA1 Proteins) activity, accompanied by a shift to a moderate water- and salt-wasting phenotype. Thus we confirm the physiologically relevant role of AMPK (show PRKAA1 Proteins) in the kidney.

  2. AMPK (show PRKAA1 Proteins) phosphorylation of cortactin (show CTTN Proteins) followed by SIRT1 (show SIRT1 Proteins) deacetylation modulates the interaction of cortactin (show CTTN Proteins) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Proteins)/SIRT1 (show SIRT1 Proteins) coregulated cortactin (show CTTN Proteins)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Proteins) subcellular translocation/activation and is atheroprotective.

  3. Findings show that decreased AMPK (show PRKAA1 Proteins) activity in muscle leads to decreased voluntary activity which is not due to secondary abnormalities in dopamine levels in the ventral striatum or sensitivity to cocaine. Thus, decreased voluntary activity in AMPK (show PRKAA1 Proteins) muscle deficient mice is most likely unrelated to regulation of brain dopamine content and metabolism.

  4. Hypoxia reduces HNF4alpha/MODY1 (show HNF4A Proteins) protein expression in pancreatic beta-cells by activating AMP-activated protein kinase.

  5. These studies reveal a novel mechanism in which CYP2J2 (show CYP2J2 Proteins) and epoxyeicosatrienoic acids enhanced Akt1 (show AKT1 Proteins) nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.

  6. Loss of AMPKalpha2 is associated with impaired control of vesicular stomatitis virus infection.

  7. AMPK (show PRKAA1 Proteins)-mediated HSPB1 (show HSPB1 Proteins) expression enhanced insulin (show INS Proteins) sensitivity in the skeletal muscle.

  8. Collectively, our data support the notion that the activation of AMPKalpha2 contributes to the atrophic effects of denervation.

  9. The activation of AMPKalpha2 in neutrophils is a decisive event in the initiation of vascular repair after ischemia.

  10. AMPKalpha2 deletion induces vascular smooth muscle cell phenotype switching and promotes features of atherosclerotic plaque.

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. Single SNP and haplotype analyses revealed weak associations between the PRKAA2 genotypes and loin muscle area in the investigated populations.

PRKAA2 Protein Profile

Protein Summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Alternative names and synonyms associated with PRKAA2

  • protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2)
  • protein kinase, AMP-activated, alpha 2 catalytic subunit (PRKAA2)
  • protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2)
  • 2310008I11Rik protein
  • A830082D05 protein
  • Ampk protein
  • AMPK2 protein
  • AMPKA2 protein
  • AMPKalpha2 protein
  • PRKAA protein
  • prkaa1 protein
  • PRKAA2 protein

Protein level used designations for PRKAA2

SNF1-like protein AMPK , 5'-AMP-activated protein kinase catalytic subunit alpha-2 , 5'-AMP-activated protein kinase alpha-2 catalytic subunit , protein kinase, AMP-activated, alpha 2 catalytic subunit , AMPKalpha2 , ampka2 , AMP-activated protein kinase alpha 2 catalytic subunit , ACACA kinase , AMPK subunit alpha-2 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , 5'-AMP-activated protein kinase, catalytic alpha-2 chain , AMPK-alpha-2 chain , AMP-activated protein kinase , AMPK alpha-2 chain , AMP-activated protein kinase alpha-2 variant B , AMP-activated protein kinase alpha 2 , protein kinase AMP-activated alpha 2 catalytic subunit , AMPK-activated protein kinase alpha-2 subunit

GENE ID SPECIES
399172 Xenopus laevis
429110 Gallus gallus
445012 Canis lupus familiaris
572074 Danio rerio
741802 Pan troglodytes
780945 Meleagris gallopavo
100019066 Monodelphis domestica
100127210 Ovis aries
100172060 Pongo abelii
100216099 Xenopus (Silurana) tropicalis
5563 Homo sapiens
538954 Bos taurus
78975 Rattus norvegicus
108079 Mus musculus
489571 Canis lupus familiaris
397504 Sus scrofa
100034159 Equus caballus
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