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Browse our PRKAA2 Proteins (PRKAA2)

Full name:
Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit Proteins (PRKAA2)
On www.antibodies-online.com are 8 Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) Proteins from 3 different suppliers available. Additionally we are shipping PRKAA2 Antibodies (229) and PRKAA2 Kits (11) and many more products for this protein. A total of 259 PRKAA2 products are currently listed.
Synonyms:
2310008I11Rik, A830082D05, Ampk, AMPK2, AMPKA2, AMPKalpha2, PRKAA, prkaa1, PRKAA2
list all proteins Gene Name GeneID UniProt
PRKAA2 5563 P54646
Rat PRKAA2 PRKAA2 78975 Q09137
PRKAA2 108079 Q8BRK8

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PRKAA2 Proteins (PRKAA2) by Origin

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Human Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. These data are in accordance with R6 binding directly to AMPKbeta2 when both proteins detach from the diminishing glycogen (show GYS1 Proteins) particle, which is simultaneous with increased AMPKbeta2 Thr (show TRH Proteins)-148 autophosphorylation.

  2. p-AMPKalpha (show GRK4 Proteins) was associated with cervical carcinogenesis, and high expression of AMPKalpha2 was correlated with better disease-free survival in patients with early-stage cervical cancer

  3. AMPK-alpha-2 binds to ER-alpha (show ESR1 Proteins), as well as ER-beta (show ESR2 Proteins).

  4. Data show that activated AMP-activated protein kinase (AMPK) limits retinal pigment epithelial cells (RPE (show RPE Proteins)) phagocytic activity by abolishing retinal photoreceptor cell outer segment (POS)-induced activation of c-mer proto-oncogene tyrosine kinase (MerTK (show MERTK Proteins)).

  5. AMPKalpha (show GRK4 Proteins) signalling suppresses EMT (show ITK Proteins) and secretion of chemokines in renal tubular epithelia through interaction with CK2beta (show CSNK2B Proteins) to attenuate renal injury.

  6. Data (including data from studies in knockout mice) suggest AMPK (show PRKAA1 Proteins) activation (AMPKa1 (show PRKAA1 Proteins) or AMPKa2) suppresses inflammation in vascular smooth muscle cells by down-regulation of STAT1 (show STAT1 Proteins) signaling and up-regulation of MKP-1 (dual specificity phosphatase 1 (show DUSP1 Proteins)).

  7. A subunit composition of AMPK (alpha2beta2gamma1) is preferred for colorectal cancer cell survival, at least in part, by stabilizing the tumor-specific expression of PGC1B.

  8. CaMKKbeta-AMPKalpha2 signaling contributes to mitotic Golgi fragmentation and the G2/M transition in mammalian cells.

  9. The basal level of ERK (show EPHB2 Proteins) phosphorylation was suppressed in cells treated with siRNA against PRKAA2 (AMPK-knockdown cells).

  10. These data define the master metabolic regulator AMPK (show PRKAA1 Proteins) as a novel stress granule constituent that also controls their biogenesis.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).

  2. The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported.

  3. These data show that the AMPK (show PRKAA1 Proteins) activator AICAR (show ATIC Proteins) is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK (show PRKAA1 Proteins) [AMP-activated protein kinase alpha (show PAK1 Proteins) 1 subunit].

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. AMPKalpha2 isoform plays a fundamental role in anti-oxidant stress and anti-senescence

  2. AMPKalpha2 is involved in post-transcriptional and not transcriptional regulation of PDK4 (show PDK4 Proteins) in muscle.

  3. Deletion of the AMPK (show PRKAA1 Proteins) alpha-subunits improves oral but not intraperitoneal glucose tolerance.

  4. PKD1 (show PKD1 Proteins) phosphorylates AMPKalpha2 at Ser485/491, thus diminishing AMPK (show PRKAA1 Proteins) activity.

  5. In conclusion, our findings reveal a new functional role of activating AMPK (show PRKAA1 Proteins) in the CNS to attenuate inflammatory responses and acute lung injury in sepsis.

  6. Data (including data from knockout mice) suggest expression levels/phosphorylation of Ampk (show PRKAA1 Proteins)-alpha1/Ampk (show PRKAA1 Proteins)-alpha2 are up-regulated in intestinal mucosa by ingestion of alpha-linolenic acid (which inhibits high-fat diet-induced hypertriglyceridemia).

  7. AMPKalpha (show GRK4 Proteins) signalling suppresses EMT (show ITK Proteins) and secretion of chemokines in renal tubular epithelia through interaction with CK2beta (show CSNK2B Proteins) to attenuate renal injury.

  8. Data (including data from studies in knockout mice) suggest that AMPKa1 (show PRKAA1 Proteins) and AMPKa2 are key in gene expression regulation in skeletal muscle in acute exercise studies but not in longer exercise training adaptation studies.

  9. the current data suggests that activation of AMPK (show PRKAA1 Proteins) signaling is sufficient but not required for exercise-induced accumulation in mitochondrial FAT/CD36 (show CD36 Proteins).

  10. The increase in nuclear PPARalpha (show PPARA Proteins) protein by four-week exercise training under the intermittent hypoxia was dependent on AMPKalpha2 activation.

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) interaction partners

  1. Single SNP and haplotype analyses revealed weak associations between the PRKAA2 genotypes and loin muscle area in the investigated populations.

PRKAA2 Protein Profile

Protein Summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Alternative names and synonyms associated with PRKAA2

  • protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2)
  • protein kinase, AMP-activated, alpha 2 catalytic subunit (PRKAA2)
  • protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2)
  • 2310008I11Rik protein
  • A830082D05 protein
  • Ampk protein
  • AMPK2 protein
  • AMPKA2 protein
  • AMPKalpha2 protein
  • PRKAA protein
  • prkaa1 protein
  • PRKAA2 protein

Protein level used designations for PRKAA2

SNF1-like protein AMPK , 5'-AMP-activated protein kinase catalytic subunit alpha-2 , 5'-AMP-activated protein kinase alpha-2 catalytic subunit , protein kinase, AMP-activated, alpha 2 catalytic subunit , AMPKalpha2 , ampka2 , AMP-activated protein kinase alpha 2 catalytic subunit , ACACA kinase , AMPK subunit alpha-2 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , 5'-AMP-activated protein kinase, catalytic alpha-2 chain , AMPK-alpha-2 chain , AMP-activated protein kinase , AMPK alpha-2 chain , AMP-activated protein kinase alpha-2 variant B , AMP-activated protein kinase alpha 2 , protein kinase AMP-activated alpha 2 catalytic subunit , AMPK-activated protein kinase alpha-2 subunit

GENE ID SPECIES
399172 Xenopus laevis
429110 Gallus gallus
445012 Canis lupus familiaris
572074 Danio rerio
741802 Pan troglodytes
780945 Meleagris gallopavo
100019066 Monodelphis domestica
100127210 Ovis aries
100172060 Pongo abelii
100216099 Xenopus (Silurana) tropicalis
5563 Homo sapiens
538954 Bos taurus
78975 Rattus norvegicus
108079 Mus musculus
489571 Canis lupus familiaris
397504 Sus scrofa
100034159 Equus caballus
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