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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
CD82 (CD83) antibody
|Synonyms||BL11, HB15, R2, 4F9, C33, IA4, ST6, GR15, KAI1, SAR2, TSPAN27|
Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Functional Studies (Func)
|5 references available|
|Quantity||0.1 mg (Variants)|
|Price||319.44 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Immunogen||C91/PL (human HTLV-1+ T cell line)|
|Description||The mouse monoclonal antibody C33 recognizes CD82 (KAI1), a member of the tetraspanin family, which forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules. These complexes influence adhesion, morphology, activation, proliferation and differentiation of B, T and other cells. CD82 regulates cytoskeleton rearrangement and may participate in the turnover of the tetraspanin complex members. Besides in the plasma membrane, CD82 is localized also in endosome/lysosome compartments. Tumour-suppressive roles of CD82 have been demonstrated.|
|Specificity||The antibody C33 reacts with CD82, a widely expressed cell surface protein of the tetraspanin family. CD82 is also found in endosome/lysosome compartments.|
CD and Related Antigens (Human)
|Buffer||Phosphate buffered saline (PBS) pH 7.4|
|Storage||Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.|
|Research Area||Cancer, Transcription Factors, CD Antigens, Adaptive Immunity, Surface Receptors of Immune Cells|
|Restrictions||For Research Use only|
Fukudome, Furuse, Imai et al.: "Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells." in: Journal of virology, Vol. 66, Issue 3, pp. 1394-401, 1992 (PubMed).
Imai, Kakizaki, Nishimura et al.: "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 3, pp. 1229-39, 1995 (PubMed).
Imai, Yoshie: "C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 11, pp. 6470-81, 1994 (PubMed).
Ueda, Ichikawa, Tamaru et al.: "Expression of the KAI1 protein in benign prostatic hyperplasia and prostate cancer." in: The American journal of pathology, Vol. 149, Issue 5, pp. 1435-40, 1996 (PubMed).
Escola, Kleijmeer, Stoorvogel et al.: "Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes." in: The Journal of biological chemistry, Vol. 273, Issue 32, pp. 20121-7, 1998 (PubMed).
|Hosts||Rabbit (39), Mouse (13)|
|Reactivities||Human (55), Mouse (Murine) (26), Rat (Rattus) (25), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (29), Immunofluorescence (IF) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), ELISA (15), Flow Cytometry (FACS) (12), Immunohistochemistry (IHC) (11), Immunoprecipitation (IP) (8), Functional Studies (Func) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 647 (3), PE (3), Alexa Fluor 700 (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (13), AA 253-267 (1)|