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CD9 antibody (CD9) (Biotin)

Details for Product anti-CD9 Antibody No. ABIN1043025, Supplier: Log in to see
Antigen
  • BTCC-1
  • DRAP-27
  • MIC3
  • MRP-1
  • TSPAN-29
  • TSPAN29
  • Tspan29
Reactivity
Mouse (Murine)
440
127
60
38
38
34
26
24
20
13
8
7
7
7
7
6
3
1
1
Host
Rat
392
98
78
Clonality (Clone)
Monoclonal ()
Conjugate
This CD9 antibody is conjugated to Biotin
67
66
39
15
12
11
10
10
10
9
9
8
8
8
8
8
6
5
5
5
2
2
2
2
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
458
254
108
83
77
66
59
48
40
34
5
4
2
2
2
2
1
1
1
1
1
Supplier
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Available images

Immunogen Permeabilized murine bone marrow-derived mast cells (BMMC).
Clone EM-04
Isotype IgG1
Specificity The rat monoclonal antibody EM-04 recognizes CD9 antigen, a 24 kDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes.
Characteristics The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Alternative Name CD9 (CD9 Antibody Abstract)
Background CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.
Gene ID 12527
Research Area Embryogenesis, Embryonic stem cells, Reproduction, CD Antigens, Surface Receptors of Immune Cells
Application Notes Reagent is designed for flow cytometry analysis.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Western Blotting (WB) image for anti-CD9 antibody (CD9)  (Biotin) (ABIN1043025) Detection of CD9 inbone marrow-derived mast cell (BMMC) lysates by rat monoclonal EM-...
Background publications Kotha, Zhang, Longhurst, Lu, Jacobs, Cheng, Jennings: "Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia." in: Atherosclerosis, Vol. 203, Issue 2, pp. 377-86, 2009 (PubMed).

Unternaehrer, Chow, Pypaert, Inaba, Mellman: "The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 1, pp. 234-9, 2007 (PubMed).

Liu, Cao, Yang, Li, Hu, Duan: "Tetraspanin CD9 regulates invasion during mouse embryo implantation." in: Journal of molecular endocrinology, Vol. 36, Issue 1, pp. 121-30, 2006 (PubMed).

Le Naour, Rubinstein, Jasmin, Prenant, Boucheix: "Severely reduced female fertility in CD9-deficient mice." in: Science (New York, N.Y.), Vol. 287, Issue 5451, pp. 319-21, 2000 (PubMed).

Schmidt, Künemund, Wintergerst, Schmitz, Schachner: "CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1." in: Journal of neuroscience research, Vol. 43, Issue 1, pp. 12-31, 1996 (PubMed).