TNNI3 antibody

Catalog No. ABIN1045363

Product Details anti-TNNI3 Antibody

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNNI3 antibody is un-conjugated

Application: ELISA

Specificity: Reacts equally with free cardiac troponin I and cardiac troponin I forming complexes with other troponin components. Not affected by heparin, phosphorylation and oxidation.

Cross-Reactivity: Human

Cross-Reactivity (Details): No cross-reactivity with skeletal muscle troponin I.

Purification: Protein G purified

Purity: > 95 %

Immunogen: Recombinant Human Cardiac Troponin I protein

Clone: 11D2E10

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Other species are not tested. Please decide the specificity by homology

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

References for anti-TNNI3 antibody (ABIN1045363)

Stein, Janjua, Matta, Pathak, Jaweesh, Alrifai, Chughtai: "Prognosis based on creatine kinase isoenzyme MB, cardiac troponin I, and right ventricular size in stable patients with acute pulmonary embolism." in: The American journal of cardiology, Vol. 107, Issue 5, pp. 774-7, (2011) (PubMed).

Goel, Beith: "Troponin I as a predictor for trastuzumab-related cardiotoxicity: current data do not provide mechanistic insights or allow for incorporation into clinical practice." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 29, Issue 7, pp. e175-6, (2011) (PubMed).

Xue, Clopton, Peacock, Maisel: "Serial changes in high-sensitive troponin I predict outcome in patients with decompensated heart failure." in: European journal of heart failure, Vol. 13, Issue 1, pp. 37-42, (2010) (PubMed).

Paparella, Scrascia, Paramythiotis, Guida, Magari, Malvindi, Favale, de Luca Tupputi Schinosa: "Preoperative cardiac troponin I to assess midterm risks of coronary bypass grafting operations in patients with recent myocardial infarction." in: The Annals of thoracic surgery, Vol. 89, Issue 3, pp. 696-702, (2010) (PubMed).

John, Woodward, Wang, Yan, Fisher, Kinasewitz, Heiselman: "Troponin-I as a prognosticator of mortality in severe sepsis patients." in: Journal of critical care, Vol. 25, Issue 2, pp. 270-5, (2010) (PubMed).

van Geene, van Swieten, Noyez: "Cardiac troponin I levels after cardiac surgery as predictor for in-hospital mortality." in: Interactive cardiovascular and thoracic surgery, Vol. 10, Issue 3, pp. 413-6, (2010) (PubMed).

Napan, Kashinath, Kadri, Orig, Khadra: "Prognostic significance of preprocedural troponin-I in patients with non-ST elevation acute coronary syndromes undergoing percutaneous coronary intervention." in: Coronary artery disease, Vol. 21, Issue 5, pp. 261-5, (2010) (PubMed).

Bonaca, Scirica, Sabatine, Dalby, Spinar, Murphy, Jarolim, Braunwald, Morrow: "Prospective evaluation of the prognostic implications of improved assay performance with a sensitive assay for cardiac troponin I." in: Journal of the American College of Cardiology, Vol. 55, Issue 19, pp. 2118-24, (2010) (PubMed).

Tsutamoto, Kawahara, Nishiyama, Yamaji, Fujii, Yamamoto, Horie: "Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure." in: American heart journal, Vol. 159, Issue 1, pp. 63-7, (2010) (PubMed).

Oshima, Kunimoto, Takahashi, Mohara, Takeyoshi, Hinohara, Okawa, Saito: "Postoperative cardiac troponin I (cTnI) level and its prognostic value for patients undergoing mitral valve surgery." in: International heart journal, Vol. 51, Issue 3, pp. 166-9, (2010) (PubMed).

Zahid, Good, Singla, Sonel: "Clinical significance of borderline elevated troponin I levels across different assays in patients with suspected acute coronary syndrome." in: The American journal of cardiology, Vol. 104, Issue 2, pp. 164-8, (2009) (PubMed).

Fruchter, Yigla: "Cardiac troponin-I predicts long-term mortality in chronic obstructive pulmonary disease." in: COPD, Vol. 6, Issue 3, pp. 155-61, (2009) (PubMed).

Alonso Martínez, Annicchérico Sánchez, Urbieta Echezarreta, García Sanchotena, Ezcurra Ibáñez, Lasa Inchausti: "[Clinical usefulness of troponin I in acute pulmonary embolism]." in: Medicina clínica, Vol. 133, Issue 6, pp. 201-5, (2009) (PubMed).

Apple: "Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MB." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 284, Issue 2, pp. 151-9, (1999) (PubMed).

Target Details for TNNI3

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Alternative Name: TNNI3 (TNNI3 Products)

Synonyms: CMD1FF antibody, CMD2A antibody, CMH7 antibody, RCM1 antibody, TNNC1 antibody, cTnI antibody, CMD1Z antibody, CMH13 antibody, TN-C antibody, TNC antibody, TNNC antibody, Tn1 antibody, TnIc antibody, ctnIc antibody, XTnIc antibody, c-troponin antibody, cTNT antibody, cmh7 antibody, ctni antibody, tnnc1 antibody, TNNI3 antibody, TnI antibody, cTNI antibody, AI874626 antibody, TnC antibody, cTnC antibody, tncc antibody, Tncc antibody, troponin I3, cardiac type antibody, troponin C1, slow skeletal and cardiac type antibody, troponin I, cardiac 3 antibody, troponin I type 3 (cardiac) antibody, troponin I3, cardiac type S homeolog antibody, troponin I3, cardiac type L homeolog antibody, cardiac troponin I antibody, troponin C, cardiac/slow skeletal antibody, TNNI3 antibody, TNNC1 antibody, Tnni3 antibody, tnni3.S antibody, tnni3.L antibody, tnni3 antibody, LOC100462680 antibody, Tnnc1 antibody

Background:

Background: Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.

Aliases: CTnI

UniProt: P19429