Myoglobin antibody

Catalog No. ABIN1045879

Product Details anti-Myoglobin Antibody

Target: Myoglobin (MB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Myoglobin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Specific for Human Myoglobin denatured and native forms

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Human Myoglobin protein

Isotype: IgG1

Application Details

Application Notes: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Other species are not tested. Please decide the specificity by homology

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.03 % Proclin 300, 50 % Glycerol, 0.01 M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.

Storage: -20 °C

Storage Comment: Shipped at 4 °C Upon delivery aliquot and store at -24 °C or -84 °C.

References for anti-Myoglobin antibody (ABIN1045879)

Karabay, Tuna, Ogutlu, Gozdas: "High ferritin and myoglobin level in legionella pneumonia: a case report and review of literature." in: Indian journal of pathology & microbiology, Vol. 54, Issue 2, pp. 381-3, (2011) (PubMed).

Liu, Hou, Liu, Zhang, Zhao, Ma, Zhong, Song: "[The value of determination of serum myoglobin in estimation of degree of illness and prognosis of patients with sepsis in Xining area]." in: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, Vol. 23, Issue 2, pp. 85-7, (2011) (PubMed).

Mula-Abed, Al-Sinani, Al-Hashmi: "Serum myoglobin in patients with thyroid dysfunction." in: Sultan Qaboos University medical journal, Vol. 9, Issue 1, pp. 37-41, (2011) (PubMed).

Kristiansen, Hu, Wichmann, Stiehl, Rose, Gerhardt, Bohnert, ten Haaf, Moch, Raleigh, Varia, Subarsky, Scandurra, Gnaiger, Gleixner, Bicker, Gassmann, Hankeln, Dahl, Gorr: "Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?" in: The Journal of biological chemistry, Vol. 286, Issue 50, pp. 43417-28, (2011) (PubMed).

Orak, Ustündağ, Güloğlu, Gökhan, Alyan: "Relation between serum Pro-Brain natriuretic peptide, myoglobin, CK levels and morbidity and mortality in high voltage electrical injuries." in: Internal medicine (Tokyo, Japan), Vol. 49, Issue 22, pp. 2439-43, (2010) (PubMed).

Kasaoka, Todani, Kaneko, Kawamura, Oda, Tsuruta, Maekawa: "Peak value of blood myoglobin predicts acute renal failure induced by rhabdomyolysis." in: Journal of critical care, Vol. 25, Issue 4, pp. 601-4, (2010) (PubMed).

Goksu, Oktay, Kilicaslan, Kartal: "Seizure or syncope: the diagnostic value of serum creatine kinase and myoglobin levels." in: European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Vol. 16, Issue 2, pp. 84-6, (2009) (PubMed).

Rodríguez-Capote, Balion, Hill, Cleve, Yang, El Sharif: "Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review." in: Clinical chemistry, Vol. 55, Issue 12, pp. 2190-7, (2009) (PubMed).

Moselhy, Demerdash: "Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction." in: Clinical biochemistry, Vol. 42, Issue 1-2, pp. 78-82, (2008) (PubMed).

Kontos, Garg, Anderson, Roberts, Ornato, Tatum, Jesse: "Ability of myoglobin to predict mortality in patients admitted for exclusion of myocardial infarction." in: The American journal of emergency medicine, Vol. 25, Issue 8, pp. 873-9, (2007) (PubMed).

Loun, Astles, Copeland, Sedor: "Adaptation of a quantitative immunoassay for urine myoglobin. Predictor in detecting renal dysfunction." in: American journal of clinical pathology, Vol. 105, Issue 4, pp. 479-86, (1996) (PubMed).

Laios, Caruk, Wu: "Myoglobin clearance as an early indicator for rhabdomyolysis-induced acute renal failure." in: Annals of clinical and laboratory science, Vol. 25, Issue 2, pp. 179-84, (1995) (PubMed).

Lovece, Kagen: "Sensitive rapid detection of myoglobin in serum of patients with myopathy by immunoturbidimetric assay." in: The Journal of rheumatology, Vol. 20, Issue 8, pp. 1331-4, (1993) (PubMed).

Nicholson: "Serum myoglobin in muscular dystrophy and carrier detection." in: Journal of the neurological sciences, Vol. 51, Issue 3, pp. 411-26, (1981) (PubMed).

"[Preliminary experimental morphologic and electron microscopic studies of the connection between acupuncture points on the limb and segments of the spinal cord]." in: Zhonghua yi xue za zhi, Vol. 3, pp. 144-50, (1974) (PubMed).

Kagen: "Myoglobinemia and myoglobinuria in patients with myositis." in: Arthritis and rheumatism, Vol. 14, Issue 4, pp. 457-64, (1971) (PubMed).

Target Details for Myoglobin

Target: Myoglobin (MB)

Alternative Name: Myoglobin (MB Products)

Synonyms: PVALB antibody, AI325109 antibody, zgc:65819 antibody, zgc:77764 antibody, MB antibody, DKFZp468H096 antibody, myg antibody, mb antibody, MYF4 antibody, bHLHc3 antibody, myo antibody, Myoglobin antibody, myoglobin antibody, myogenin antibody, MB antibody, Mb antibody, mb antibody, myg antibody, Myog antibody

Background: Myoglobin is a small heme containing protein (153 amino acid residues, molecular weight (w/o heme) 17053 Da and theoretical pI=7.29) responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.
Synonyms: myoglobin,MB,MGC13548,PVALB

UniProt: P02144

Pathways: Brown Fat Cell Differentiation