MECR antibody (C-Term)

Catalog No. ABIN1077414

Product Details anti-MECR Antibody

Target: MECR (Mitochondrial Trans-2-Enoyl-CoA Reductase (MECR))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MECR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least two isoforms of MECR are known to exist, this antibody will detect both isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal MECR antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MECR.

Isotype: IgG

Application Details

Application Notes: MECR antibody can be used for detection of MECR by Western blot at 1 - 2 μg/mL.

Comment:

(CT) Mitochondrial trans-2-enoyl-CoA reductase

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: MECR antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for MECR

Target: MECR (Mitochondrial Trans-2-Enoyl-CoA Reductase (MECR))

Alternative Name: MECR (MECR Products)

Synonyms: CGI-63 antibody, FASN2B antibody, NRBF1 antibody, AI195831 antibody, Nrbf1 antibody, mitochondrial trans-2-enoyl-CoA reductase antibody, MECR antibody, Mecr antibody

Background: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
Synonyms: Mitochondrial trans-2-enoyl-CoA reductase, nuclear receptor-binding factor 1, NRBF1, CGI-63, FASN2B

Molecular Weight: 41 kDa (calculated)

Gene ID: 51102

NCBI Accession: NP_057095