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CD31 antibody (Platelet/endothelial Cell Adhesion Molecule)

Details for Product anti-PECAM1 Antibody No. ABIN108424, Supplier: Log in to see
Antigen
  • CD31
  • CD31/EndoCAM
  • GPIIA'
  • PECA1
  • PECAM-1
  • endoCAM
  • C85791
  • Cd31
  • Pecam
Reactivity
Human
607
267
106
52
19
17
16
16
14
10
5
4
3
1
Host
Mouse
548
191
155
8
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD31 antibody is un-conjugated
100
77
76
39
12
10
9
7
7
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
532
316
235
156
152
134
115
75
25
22
12
11
11
11
10
10
8
5
5
3
3
3
2
2
2
1
1
1
1
1
1
Supplier
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Immunogen Monoclonal antibody to PECAM-1 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Ulex Europaeus-agglutinin-I reactive glycoproteins from cultured human umbilical vein endothelial cells isolated by lecitin-affinity chromatography were used as immunogen
Clone CE6
Isotype IgG1
Specificity The antibody reacts with Mr 135 000 PECAM-1 polypeptide from leukocytes and endothelial cells. Detects all endothelial cells in breast. Shows erythroid differentiation in human leukemic cells.
Alternative Name PECAM-1 (PECAM1 Antibody Abstract)
Background PECAM-1 (CE6) monoclonal antibody against PECAM-1 was produced to characterize human leukemic cells. PECAM-1 is typically an antigen that is shared by both endothelial and distinct hematopoietic cells. It is widely expressed among leukocytes and functions as cell adhesion molecule for these cells. PECAM-1 reactivity can be interpreted as a further evidence for megakaryocytic nature of distinct cell lines has been shown. However, a new useful application for this monoclonal antibody appears to be its very high reactivity against human endothelial cells. A recent review article states that in contrast to other applied endothelial markers, for instance PAL-E monoclonal antibody to endothelial cells and antibodies to factor VIII-related antigen, CE6 monoclonal antibody, reacts with all endothelial cells in human breast.
Research Area Extracellular Matrix
Application Notes No reactivity with paraffin sections. Working dilution in western blotting is at least 1:1000
Restrictions For Research Use only
Storage 4 °C
Supplier Images
 image for anti-CD31 antibody (Platelet/endothelial Cell Adhesion Molecule) (ABIN108424) Carcinoma of the breast (MAb CE6, PECAM-1)
Immunohistochemistry (IHC) image for anti-CD31 antibody (Platelet/endothelial Cell Adhesion Molecule) (ABIN108424) anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody (Image 2)
Background publications Tani, Ylänne, Virtanen: "Expression of megakaryocytic and erythroid properties in human leukemic cells." in: Experimental hematology, Vol. 24, Issue 2, pp. 158-68, 1996 (PubMed).

Ronnov-Jessen L, Petersen OW, Bissell MJ: "Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction." in: Physiol Rev, Vol. 76, Issue 1, pp. 69-125, 1996 (PubMed).