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Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) antibody

Details for Product No. ABIN108540, Supplier: Log in to see
Antigen
  • 1700012N19Rik
  • HSPC082
  • SIP-1
  • sip1
  • Sip1
  • SIP1
  • SIP1-delta
  • sip1-delta
  • SMADIP1
  • ZFHX1B
Reactivity
Mouse (Murine), Human, Xenopus laevis
77
46
40
1
1
Host
Mouse
67
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
61
23
21
17
13
12
9
5
2
2
1
Supplier
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Immunogen His-Gemin 2 fusion protein (AA 12 - 280, starting at 2nd methionine).
Clone 2E17
Isotype IgG1
Characteristics Myeloma fusion partners:
SP2/0
Detects a band of approximately 34 kDa
Purification Protein A
Alternative Name Gemin 2 (GEMIN2 Antibody Abstract)
Background Synonyms:
Component of gems 2 antibody,GEMI2_HUMAN antibody,Gemin-2 antibody,gemin2 antibody,SIP 1antibody,SIP-1 antibody,SIP1 antibody,SIP1 delta antibody,SMN interacting protein 1 antibody,SMNinteracting protein 1 delta antibody,SMN-interacting protein 1 antibody,Survival interacting protein 1antibody,Survival of motor neuron protein interacting protein 1 antibody,Survival of motor neuronprotein-interacting protein 1 antibody
UniProt O42260
Research Area Neurology
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try: Flow Cyt: Use 1µg for 106 cells WB: Use at an assay dependent dilution.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Storage 4 °C
Supplier Images
 image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) antibody (ABIN108540) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) antibody
 image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) antibody (ABIN108540) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) antibody (Image 2)
Product cited in: Sanchez, Dury, Murray, Biondi, Tadesse, El Fatimy, Kothary, Charbonnier, Khandjian, Côté: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, 2013 (PubMed).

Wu, Whye, Glazewski, Choe, Kerr, Lee, Mason, Wang: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, 2011 (PubMed).

Takizawa, Qing, Takaku, Ishida, Morozumi, Tsujita, Kogame, Hirota, Takahashi, Shibata, Kurumizaka, Takeda: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, 2010 (PubMed).

Burnett, Muñoz, Tandon, Kwon, Sumner, Fischbeck: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, 2009 (PubMed).

Walker, Rajendra, Saieva, Fuentes, Pellizzoni, Matera: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, 2008 (PubMed).

Morency, Sabra, Catez, Texier, Lomonte: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, 2007 (PubMed).

Renvoisé, Khoobarry, Gendron, Cibert, Viollet, Lefebvre: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, 2006 (PubMed).

Liu, Fischer, Wang, Dreyfuss: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins." in: Cell, Vol. 90, Issue 6, pp. 1013-21, 1997 (PubMed).