CD6 antibody (AA 472-668)

Catalog No. ABIN1098118

This Mouse Monoclonal antibody specifically detects CD6 in IHC and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for CD6 antibody (AA 472-668) (ABIN1098118)

Target: CD6

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 6B9

Product Details anti-CD6 Antibody

Binding Specificity: AA 472-668

Purpose: CD6 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD6 (AA: 472-668) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD6 antibody (ABIN1098118)

Alonso, Buors, Le Dantec, Hillion, Pers, Saraux, Montero, Marianowski, Loisel, Devauchelle, Youinou, Renaudineau: "Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome." in: Journal of autoimmunity, Vol. 35, Issue 4, pp. 336-41, (2010) (PubMed).

Sarrias, Farnós, Mota, Sánchez-Barbero, Ibáñez, Gimferrer, Vera, Fenutría, Casals, Yélamos, Lozano: "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 28, pp. 11724-9, (2007) (PubMed).

Target Details for CD6

Target: CD6

Alternative Name: CD6

Background: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 71.8 kDa

Gene ID: 923

UniProt: P30203