BPDE-DNA antibody
BPDE-DNA
Reactivity: Mammalian
IHC (p), EIA, IF, IP
Host: Mouse
Monoclonal
5D11
unconjugated
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- Target See all BPDE-DNA products
- BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))
- Reactivity
- Mammalian
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BPDE-DNA antibody is un-conjugated
- Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunoprecipitation (IP)
- Purification
- Protein G
- Immunogen
- BPDE-I-DNA complexed with methylated BSA
- Clone
- 5D11
- Isotype
- IgG2a
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2 - 8 °C.
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- Target
- BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))
- Alternative Name
- BPDE-DNA (BPDE-DNA Products)
- Background
- A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representative PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.
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