TYROBP antibody
Quick Overview for TYROBP antibody (ABIN110576)
Target
See all TYROBP AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- 4 °C
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- TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
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Alternative Name
- DAP12
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Background
- DAP12 is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
Target
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