TYROBP antibody (C-Term)

Catalog No. ABIN955408

This Rabbit Polyclonal antibody specifically detects TYROBP in WB, FACS, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for TYROBP antibody (C-Term) (ABIN955408)

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYROBP antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TYROBP Antibody

Binding Specificity: AA 84-113, C-Term

Specificity: This antibody detects TYROBP / DAP12 (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 84~113 amino acids from the C-terminal region of human TYROBP

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Alternative Name: TYROBP / DAP12

Background: TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.Synonyms: DNAX-activation protein 12, KARAP, Killer-activating receptor-associated protein, TYRO protein tyrosine kinase-binding protein

Gene ID: 7305

NCBI Accession: NP_003323