NIK (NF-kB-Inducing Kinase) antibody

Antigen: NIK (NF-kB-Inducing Kinase)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN110581

Additional Information

Format: Protein A purified, 0.1% sodium azide, Lyophilized

Description: NIK (NF-. B-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-. B activity. NIK, initially isolated from a human B cell cDNA library, contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to I. B phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-. B activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-. B activation.

Application Details

Storage: 4 C for short term storage or -20 C in small aliquots for long term storage. Avoid repeated freeze and thaw. Reconstitute to 1 mg/ml by adding 200 µ l PBS

Research Area: Transcription Factors

Restrictions: For Research Use only