MAP3K14 antibody

Catalog No. ABIN110581

This Rabbit Polyclonal antibody specifically detects MAP3K14 in WB. It exhibits reactivity toward Human.

Quick Overview for MAP3K14 antibody (ABIN110581)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP3K14 Antibody

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: 4 °C

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: NIK (NF-kB-Inducing Kinase)

Background: NIK (NF-. B-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-. B activity. NIK, initially isolated from a human B cell cDNA library, contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to I. B phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-. B activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-. B activation.

Pathways: NF-kappaB Signaling, TCR Signaling