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Keratin 10 (KRT10) antibody

Details for Product No. ABIN1106898, Supplier: Log in to see
Antigen
  • KRT10
  • KRT9
  • BCIE
  • BIE
  • CK10
  • EHK
  • K10
  • KPP
  • Ka10
  • Ker10
  • D130054E02Rik
  • K1C1
  • Krt-1.10
  • Krt1-10
  • keratin 10
  • keratin, type I cytoskeletal 10-like
  • KRT10
  • LOC771977
  • krt10
  • Krt10
Reactivity
Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Zebrafish (Danio rerio)
356
134
78
74
63
10
5
3
3
2
1
1
1
1
Host
Mouse
249
111
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
17
13
12
9
8
8
7
7
7
7
7
7
7
7
6
6
5
4
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
203
156
148
142
112
105
75
52
33
14
11
6
3
2
1
1
1
Options
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Immunogen Cytokeratins from the Human epidermis
Clone RKSE60
Isotype IgG1
Specificity RKSE60 reacts exclusively with Cytokeratin 10 which is present in keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas.
Cross-Reactivity (Details) Species reactivity (tested):Canine, Human, Mouse, Rat, Swine, Zebrafish.
Purification Purified
Alternative Name Cytokeratin 10 (KRT10 Antibody Abstract)
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.Synonyms: CK-10, CK10, Cytokeratin-10, K10, KPP, KRT10, Keratin, Keratin-10, Type I Cytoskeletal 10
Gene ID 3858
NCBI Accession NP_000412
UniProt P13645
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized (preferably in a desiccator) at 2-8 °C and reconstituted (in aliquots) at -20 °C.
Background publications Ramaekers, van Niekerk, Poels, Schaafsma, Huijsmans, Robben, Schaart, Vooijs: "Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas." in: The American journal of pathology, Vol. 136, Issue 3, pp. 641-55, 1990 (PubMed).

Schaafsma, Ramaekers, van Muijen, Lane, Leigh, Robben, Huijsmans, Ooms, Ruiter: "Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression." in: The American journal of pathology, Vol. 136, Issue 2, pp. 329-43, 1990 (PubMed).

Smedts, Ramaekers, Robben, Pruszczynski, van Muijen, Lane, Leigh, Vooijs: "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 136, Issue 3, pp. 657-68, 1990 (PubMed).

Odin, Obrink: "Quantitative determination of the organ distribution of the cell adhesion molecule cell-CAM 105 by radioimmunoassay." in: Experimental cell research, Vol. 171, Issue 1, pp. 1-15, 1987 (PubMed).

Broers, Carney, Klein Rot, Schaart, Lane, Vooijs, Ramaekers: "Intermediate filament proteins in classic and variant types of small cell lung carcinoma cell lines: a biochemical and immunochemical analysis using a panel of monoclonal and polyclonal antibodies." in: Journal of cell science, Vol. 83, Issue 12, pp. 37-60, 1987 (PubMed).

Ramaekers, Huysmans, Schaart, Moesker, Vooijs: "Tissue distribution of keratin 7 as monitored by a monoclonal antibody." in: Experimental cell research, Vol. 170, Issue 1, pp. 235-49, 1987 (PubMed).

Puts, Moesker, Kenemans, Vooijs, Ramaekers: "Expression of cytokeratins in early neoplastic epithelial lesions of the uterine cervix." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 4, Issue 4, pp. 300-13, 1986 (PubMed).