Glial Fibrillary Acidic Protein (GFAP) antibody

Details for Product No. ABIN1107345
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Antigen
Synonyms GFAP, AI836096, cb345, etID36982.3, gfapl, wu:fb34h11, wu:fk42c12, xx:af506734, zgc:110485
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(434), (148), (145), (82), (63), (17), (15), (12), (11), (9), (6), (5), (4), (2), (2), (1), (1), (1), (1), (1)
Host
Mouse
(273), (237), (24), (10), (3), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(21), (16), (15), (8), (8), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(388), (213), (177), (174), (117), (109), (72), (41), (30), (10), (5), (5), (5), (4), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN1107345
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Immunogen GFAP from pig spinal cord.
Clone GA-8
Isotype IgG1
Specificity This antibody reacts to GFAP.
Purification Affinity chromatography
Alternative Name GFAP
Background GGlial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate- shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.
Alternate names: Glial Fibrillary Acidic Protein
Gene ID 2670
NCBI Accession NP_001124491
UniProt P14136
Research Area Stem Cells, Cytoskeleton, Glia marker, Cell/Tissue Markers, Neurology
Restrictions For Research Use only
Reconstitution Restore with 1.2% sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Glial Fibrillary Acidic Protein (GFAP) antibody anti-Glial Fibrillary Acidic Protein (GFAP) antibody
anti-Glial Fibrillary Acidic Protein (GFAP) antibody (2) anti-Glial Fibrillary Acidic Protein (GFAP) antibody (Image 2)
Background publications Brenner, Johnson, Boespflug-Tanguy et al.: "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease." in: Nature genetics, Vol. 27, Issue 1, pp. 117-20, 2001 (PubMed).

Rodriguez, Gauthier, Bertini et al.: "Infantile Alexander disease: spectrum of GFAP mutations and genotype-phenotype correlation." in: American journal of human genetics, Vol. 69, Issue 5, pp. 1134-40, 2001 (PubMed).

Validation Images
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