PTX3 antibody

Catalog No. ABIN1108797

Product Details anti-PTX3 Antibody

Target: PTX3 (Pentraxin 3 (PTX3))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This PTX3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)

Specificity: The monoclonal antibody MNB1 recognizes human pentraxin 3 (PTX3), belonging to the long pentraxin family.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G

Immunogen: Human recombinant PTX3

Clone: MNB1

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for PTX3

Target: PTX3 (Pentraxin 3 (PTX3))

Alternative Name: PTX3 (PTX3 Products)

Synonyms: fb05a06 antibody, wu:fb05a06 antibody, TNFAIP5 antibody, TSG-14 antibody, PPTX antibody, AI607804 antibody, si:ch211-272f3.3 antibody, pentraxin 3 antibody, pentraxin related gene antibody, si:ch211-272f3.3 antibody, LOC100230343 antibody, PTX3 antibody, Ptx3 antibody

Background: PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10 % of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways.Synonyms: Pentaxin-related protein PTX3, Pentraxin-related protein PTX3, TNF alpha-induced protein 5, TNFAIP5, TSG-14, TSG14, Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein

Gene ID: 5806

NCBI Accession: NP_002843

UniProt: P26022