RAG1 antibody (C-Term)

Catalog No. ABIN1108824

Product Details anti-RAG1 Antibody

Target: RAG1 (Recombination Activating Gene 1 (RAG1))

Binding Specificity: C-Term

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAG1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IIERDGSIGA WASEGNESGN KLFRRFRKMN ARQSKCYEME DVLKHHWLYT

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse.

Purification: Immunoaffinity column

Immunogen: Synthetic peptide corresponding to a near C-terminal region of mouse

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for RAG1

Target: RAG1 (Recombination Activating Gene 1 (RAG1))

Alternative Name: RAG1 / RNF74 (RAG1 Products)

Synonyms: RAG-1 antibody, rag1 antibody, RNF74 antibody, Rag-1 antibody, rag-1 antibody, rag1a antibody, recombination activating 1 antibody, recombination activating gene 1 antibody, recombination activating gene 1 S homeolog antibody, Rag1 antibody, RAG1 antibody, rag1 antibody, rag1.S antibody

Background: As a catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities.Synonyms: RAG-1, RING finger protein 74, V(D)J recombination-activating protein 1

Molecular Weight: RAG1: 119 kDa

Gene ID: 19373

NCBI Accession: NM_009019