RRAD antibody (Internal Region)

Catalog No. ABIN1108906

Product Details anti-RRAD Antibody

Target: RRAD (Ras-Related Associated with Diabetes (RRAD))

Binding Specificity: AA 36-48, Internal Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This RRAD antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes RRAD (36-48).

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Porcine, Bovine.
Species reactivity (tested):Mouse.

Purification: Affinity Chromatography

Immunogen: Peptide with sequence (C-HRRSMPVDERDLQ) from the internal region of Human RRAD (NP_004156.1). Genename: RRAD Remarks: Reported variants represent identical protein: NP_004156.1, NP_001122322.1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RRAD

Target: RRAD (Ras-Related Associated with Diabetes (RRAD))

Alternative Name: RRAD / RAD (RRAD Products)

Synonyms: ZGC:63471 antibody, RRAD antibody, RAD antibody, RAD1 antibody, REM3 antibody, Rad antibody, RRAD, Ras related glycolysis inhibitor and calcium channel regulator antibody, Ras-related associated with diabetes antibody, RRAD antibody, Rrad antibody

Background: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Synonyms: GTP-binding protein RAD, RAD1, Ras associated with diabetes

Molecular Weight: 33.2 kDa (Mouse NP_062636.2 and Human NP_004156.1).

Gene ID: 6236

NCBI Accession: NP_001122322