TRAFD1 antibody (C-Term)

Catalog No. ABIN1109296

Product Details anti-TRAFD1 Antibody

Target: TRAFD1 (TRAF-Type Zinc Finger Domain Containing 1 (TRAFD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Cow, Dog, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAFD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: TATNHVTEGI PRLDSQPQET SPELPRRRVR HQGDLSSGYL DDTKQETANG

Cross-Reactivity (Details): Species reactivity (expected):Rat, Mouse, Dog, BovineSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRAFD1 antibody: synthetic peptide directed towards the C terminal of human TRAFD1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TRAFD1

Target: TRAFD1 (TRAF-Type Zinc Finger Domain Containing 1 (TRAFD1))

Alternative Name: TRAFD1 / FLN29 (TRAFD1 Products)

Synonyms: MGC80116 antibody, fln29 antibody, MGC89491 antibody, TRAFD1 antibody, 1110008K06Rik antibody, Fln29 antibody, FLN29 antibody, TRAF-type zinc finger domain containing 1 antibody, TRAF-type zinc finger domain containing 1 L homeolog antibody, TRAF-type zinc finger domain-containing protein 1 antibody, TRAF type zinc finger domain containing 1 antibody, TRAFD1 antibody, trafd1.L antibody, trafd1 antibody, trad1 antibody, Trafd1 antibody

Background: TRAFD1 is a negative feedback regulator that controls excessive innate immune responses. It regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways and may inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. TRAFD1 may negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.Synonyms: TRAF-type zinc finger domain-containing protein 1

Gene ID: 10906

NCBI Accession: NP_006691