TRIP10 antibody (Middle Region)

Catalog No. ABIN1109339

Product Details anti-TRIP10 Antibody

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIP10 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL

Cross-Reactivity (Details): Species reactivity (expected):Rat, Mouse, Bovine, Zebrafish, African clawed frog, RabbitSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRIP10 antibody: synthetic peptide directed towards the middle region of human TRIP10.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TRIP10

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Alternative Name: TRIP10 (TRIP10 Products)

Synonyms: CIP4 antibody, HSTP antibody, STOT antibody, STP antibody, AI646975 antibody, Cip4 antibody, trip10 antibody, thyroid hormone receptor interactor 10 antibody, thyroid hormone receptor interactor 10a antibody, TRIP10 antibody, Trip10 antibody, trip10a antibody

Background: TRIP10 is required for translocation of GLUT4 to the plasma membrane in response to insulin signaling and to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. It binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules and also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. TRIP10 is further required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells and may be required for the lysosomal retention of FASLG/FASL.Synonyms: CIP4, Cdc42-interacting protein 4, Protein Felic, STOT, STP, Salt tolerant protein, TRIP-10, Thyroid receptor-interacting protein 10

Gene ID: 9322

NCBI Accession: NP_004231