XAGE1 antibody (C-Term, Isoform 1d)

Catalog No. ABIN1109518

Product Details anti-XAGE1 Antibody

Target: XAGE1 (XAGE1A) (X Antigen Family, Member 1A (XAGE1A))

Binding Specificity: C-Term, Isoform 1d

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This XAGE1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: CGFGFRRQGE DNT

Specificity: This antibody is expected to recognise Isoform d (NP_597673.1) only. Reported variants represent identical protein (NP_597673.1, NP_001091067.1, NP_001091074.1, NP_001091062.1, NP_001091065.1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide with sequence from the C-Terminus of Human XAGE1D / GAGED2 (NP_597673.1). Genename: GAGED2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for XAGE1

Target: XAGE1 (XAGE1A) (X Antigen Family, Member 1A (XAGE1A))

Alternative Name: XAGE-1 / G Antigen Family D Member 2 (XAGE1A Products)

Background: XAGE1 is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. XAGE1 is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. XAGE1 contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of XAGE1 generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.Synonyms: CT12.1, Cancer/testis antigen 12.1, GAGED2, XAGE1, XAGE1A, XAGE1B, XAGE1C, XAGE1D, XAGE1E

Gene ID: 653048

NCBI Accession: NP_001091061