YAF2 antibody (Middle Region)

Catalog No. ABIN1109525

Product Details anti-YAF2 Antibody

Target: YAF2 (YY1 Associated Factor 2 (YAF2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YAF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: KGTSTRKPRP VSQLVAQQVT QQFVPPTQSK KEKKDKVEKE KSEKETTSKK

Cross-Reactivity (Details): Species reactivity (expected):Dog, Rat, Mouse, Bovine, Chicken, African clawed frogSpecies reactivity (tested):Human

Purification: Purified on Protein A affinity column

Immunogen: The immunogen for anti-YAF2 antibody: synthetic peptide directed towards the middle region of human YAF2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the lyophised antibody at -20 °C for up to one year. Store reconstitued antibody undiluted for one month or in aliquots at -20 °C long term.

Expiry Date: 12 months

Target Details for YAF2

Target: YAF2 (YY1 Associated Factor 2 (YAF2))

Alternative Name: YAF2 (YAF2 Products)

Synonyms: MGC75686 antibody, YAF2 antibody, zgc:136577 antibody, si:ch211-155a11.5 antibody, 2810021M11Rik antibody, YY1 associated factor 2 antibody, YY1-associated factor 2 antibody, yaf2 antibody, YAF2 antibody, LOC100221270 antibody, Yaf2 antibody

Background: YAF2 interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. YAF2 contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two have been confirmed to date.Synonyms: YY1-associated factor 2

Gene ID: 10138

NCBI Accession: NP_005739