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Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1) antibody

Details for Product No. ABIN112189, Supplier: Log in to see
Antigen
  • A2MRAP
  • A2RAP
  • AA617339
  • AI790446
  • AU042172
  • C77774
  • DKFZp459I2430
  • HBP44
  • LRPAP1
  • MRAP
  • RAP
  • wu:fi20f07
  • wu:fi22c06
Reactivity
Human
73
24
15
3
2
1
1
1
Host
Mouse
64
21
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
8
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
65
39
24
16
6
5
5
4
4
1
1
1
1
Supplier
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Immunogen Human RAP.
Clone 7F1
Isotype IgG1
Specificity This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor). It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
Purification Affinity Chromatography on Protein A .
Alternative Name LRPAP1 / A2MRAP (LRPAP1 Antibody Abstract)
Background Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B, binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.Synonyms: Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, Low density lipoprotein receptor-related protein-associated protein 1, RAP
Gene ID 4043
NCBI Accession NP_002328
UniProt P30533
Application Notes Immunoblotting. Immunofluorescence. Immunohistochemistry: 1/20. Ligand-binding assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in 1 mL distilled water.
Buffer PBS buffer, pH 7.4 containing 0.5 % BSA as stabilizer.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Kounnas, Argraves, Strickland: "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330." in: The Journal of biological chemistry, Vol. 267, Issue 29, pp. 21162-6, 1992 (PubMed).