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Integral Membrane Protein 2B (ITM2B) antibody

Details for Product No. ABIN113338
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Antigen
Synonyms ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, AI256040, Bri, Bri2, Bricd2b, D14Sel6, E25BMM, itm2b, zgc:55770, zgc:85688, wu:fc05f02, MGC52745, MGC76131, ITM2B
Reactivity
Human
(33), (21), (14), (3), (2)
Host
Chicken
(25), (6), (4), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro))
(29), (17), (11), (10), (7), (4), (2), (2)
Pubmed 1 reference available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN113338
577.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide coupled to carrier protein.
Sequence CSRTVKKNIIEEN
Specificity The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.
Purification Affinity chromatography.
Alternative Name ITM2B
Background The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.
Alternate names: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI
Gene ID 9445
NCBI Accession NP_068839.1
UniProt Q9Y287
Research Area Neurology
Application Notes Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg /ml
Buffer PBS, pH 7.2, containing 0.09% sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C (Lyophilized) or reconstituted in small aliquots at -20°C.
Expiry Date 12 months
Background publications Vidal, Frangione, Rostagno et al.: "A stop-codon mutation in the BRI gene associated with familial British dementia." in: Nature, Vol. 399, Issue 6738, pp. 776-81, 1999 (PubMed).

Hosts (25), (6), (4), (4)
Reactivities (33), (21), (14), (3), (2)
Applications (29), (17), (11), (10), (7), (4), (2), (2)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (5), (4), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN113338
577.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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