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Integral Membrane Protein 2B (ITM2B) antibody

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Synonyms itm2b, zgc:55770, zgc:85688, wu:fc05f02, MGC52745, MGC76131, ITM2B, Bri, imBRI2, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, AI256040, Bri2, Bricd2b, D14Sel6, E25BMM
(43), (23), (7), (4), (1), (1), (1), (1), (1), (1)
(26), (17), (11), (4), (1)
(3), (3), (3), (3), (3), (3), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro))
(55), (36), (21), (7), (3), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 0.2 mg
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Immunogen Peptide coupled to carrier protein.
Specificity The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.
Purification Affinity chromatography.
Alternative Name ITM2B (ITM2B Antibody Abstract)
Background The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI
Gene ID 9445
NCBI Accession NP_068839
UniProt Q9Y287
Research Area Neurology
Application Notes Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg /ml
Buffer PBS, pH 7.2, containing 0.09 % sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.
Background publications Vidal, Frangione, Rostagno et al.: "A stop-codon mutation in the BRI gene associated with familial British dementia." in: Nature, Vol. 399, Issue 6738, pp. 776-81, 1999 (PubMed).

Catalog No. ABIN113338
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