ITM2B antibody (C-Term)

Catalog No. ABIN657087

Product Details anti-ITM2B Antibody

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Binding Specificity: AA 218-247, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.

Clone: RB32712

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Alternative Name: ITM2B (ITM2B Products)

Synonyms: ABRI antibody, BRI antibody, BRI2 antibody, BRICD2B antibody, E25B antibody, E3-16 antibody, FBD antibody, imBRI2 antibody, AI256040 antibody, Bri antibody, Bri2 antibody, Bricd2b antibody, D14Sel6 antibody, E25BMM antibody, itm2b antibody, zgc:55770 antibody, zgc:85688 antibody, wu:fc05f02 antibody, MGC52745 antibody, MGC76131 antibody, ITM2B antibody, itm2bl antibody, wu:fb94b03 antibody, zgc:64142 antibody, integral membrane protein 2B antibody, integral membrane protein 2Ba antibody, integral membrane protein 2B L homeolog antibody, integral membrane protein 2b antibody, integral membrane protein 2Bb antibody, ITM2B antibody, Itm2b antibody, itm2ba antibody, itm2b.L antibody, itm2b antibody, itm2bb antibody

Background: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Molecular Weight: 30338

NCBI Accession: NP_068839

UniProt: Q9Y287