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Integrin, alpha M (Complement Component 3 Receptor 3 Subunit) (ITGAM) antibody
| Antigen | Integrin, alpha M (Complement Component 3 Receptor 3 Subunit) (ITGAM) |
| Synonyms | CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, MGC117044, CR3, MAC1, Cd11b, Ly-40, Mac-1, Mac-1a, CD11b/CD18, F730045J24Rik, ITGAM, Itgam |
| Clonality | Monoclonal (M1-70) |
| Host |
 Alternatives Rat |
| Reactivity |
Alternatives Human, Mouse (Murine), Rabbit |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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4 references available |
| Catalog no. | ABIN118145 |
| Quantity | 0.25 mg (1.0 mg IgG/ml) |
| Price | 374.00 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 6 to 8 Business Days |
Additional Information
| Alternative name | CD11b |
| UniProt | P05555 |
| Immunogen | T cell enriched splenocytes from B10 mice. Spleen cells from immunised DA rats were fused with cells of the NS1/1.Ag4.1 mouse myeloma cell line |
| Cross-Reactivity | Human, Mouse (Murine), Rabbit |
| Isotype | IgG2b |
| Clone | M1-70 |
| Description | CD11b is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Alternate Names: Integrin Alpha M Chain, MAC-1. |
Application Details
| Application Notes | Immunoprecipitation. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections. Flow cytometry: 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Clone M1/70.15 has been reported to block iC3b binding to its receptor. ABIN118139 is recommended for this purpose. |
| Concentration | 1.0 mg IgG/ml |
| Purification | Purified |
| Buffer | This antibody is supplied as liquid, purified immunoglobulin fraction in PBS buffer with 0.09% sodium azide as preservative. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch. |
| Research Area | Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells |
| Restrictions | For Research Use only |
Publications
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Springer, Galfré, Secher et al.: "Mac-1: a macrophage differentiation antigen identified by monoclonal antibody." in: European journal of immunology, Vol. 9, Issue 4, pp. 301-6, 1979 (PubMed).
Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed). Beller, Springer, Schreiber: "Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor." in: The Journal of experimental medicine, Vol. 156, Issue 4, pp. 1000-9, 1983 (PubMed). Whiteland, Nicholls, Shimeld et al.: "Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 43, Issue 3, pp. 313-20, 1995 (PubMed). |
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Alternatives
Alternatives for antigen "Integrin, alpha M (Complement Component 3 Receptor 3 Subunit) (ITGAM)", type "Antibodies"
