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CD11b antibody (Integrin alpha M)

Details for Product anti-ITGAM Antibody No. ABIN118146, Supplier: Login to see New
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Synonyms CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a, CD11B, MAC-1, MAC1A, MO1A, SLEB6, C3bi
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Human, Mouse (Murine), Rabbit
(543), (428), (120), (44), (20), (17), (17), (17), (17), (11), (10), (9), (5), (4), (3), (2), (2), (1)
(454), (399), (93), (17), (4), (2)
Clonality (Clone)
Monoclonal ()
This CD11b antibody is un-conjugated
(164), (121), (85), (50), (18), (18), (11), (11), (11), (8), (7), (7), (6), (6), (6), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(770), (217), (181), (135), (114), (86), (78), (61), (45), (38), (19), (16), (7), (6), (5), (4), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Pubmed 18 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen T cell enriched splenocytes from B10 mice. Spleen cells from immunised DA Rats were fused with cells of the NS1/1.Ag4.1 mouse myeloma cell line.
Clone M1-70-15
Isotype IgG2b
Purification Affinity Chromatography on Protein G
Alternative Name CD11b (ITGAM Antibody Abstract)
Background MAC-1 is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages.Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Gene ID 10090
UniProt P05555
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptosis
Application Notes Flow cytometry: 1/50 - 1/200. Immunoprecipitation. Immunohistochemistry on frozen and paraffin sections: Clone M1/70.15 has been reported to as being suitable for use on PLP fixed paraffin embedded tissue but has not been tested for use on formalin fixed tissue. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-CD11b antibody (Integrin alpha M) (ABIN118146) Staining of mouse peritoneal macrophages with rat anti mouse CD11b (ABIN118146).
Background publications Geier, Celli: "Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis." in: Infection and immunity, Vol. 79, Issue 6, pp. 2204-14, 2011 (PubMed).

Redensek, Rathore, Berard et al.: "Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury." in: Glia, Vol. 59, Issue 4, pp. 603-14, 2011 (PubMed).

Ghasemlou, Lopez-Vales, Lachance et al.: "Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13750-9, 2010 (PubMed).

Kanu, Penicud, Hristova et al.: "The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain." in: The Journal of biological chemistry, Vol. 285, Issue 49, pp. 38534-42, 2010 (PubMed).

Chinnery, Ruitenberg, McMenamin: "Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 896-909, 2010 (PubMed).

Ferger, Campanelli, Reimer et al.: "Effects of mitochondrial dysfunction on the immunological properties of microglia." in: Journal of neuroinflammation, Vol. 7, pp. 45, 2010 (PubMed).

Samanta, Alden, Gobeske et al.: "Noggin protects against ischemic brain injury in rodents." in: Stroke; a journal of cerebral circulation, Vol. 41, Issue 2, pp. 357-62, 2010 (PubMed).

Brochard, Combadière, Prigent et al.: "Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease." in: The Journal of clinical investigation, Vol. 119, Issue 1, pp. 182-92, 2009 (PubMed).

Huang, Hossain, Wu et al.: "Role of H2-calponin in regulating macrophage motility and phagocytosis." in: The Journal of biological chemistry, Vol. 283, Issue 38, pp. 25887-99, 2008 (PubMed).

Hudcovic, Kozáková, Kolínská et al.: "Monocolonization with Bacteroides ovatus protects immunodeficient SCID mice from mortality in chronic intestinal inflammation caused by long-lasting dextran sodium sulfate treatment." in: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 58, Issue 1, pp. 101-10, 2009 (PubMed).

Kapturczak, Wasserfall, Brusko et al.: "Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse." in: The American journal of pathology, Vol. 165, Issue 3, pp. 1045-53, 2004 (PubMed).

Klingel, Schnorr, Sauter et al.: "beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis." in: The American journal of pathology, Vol. 162, Issue 5, pp. 1709-20, 2003 (PubMed).

Welt, Edelman, Simon et al.: "Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 20, Issue 12, pp. 2553-8, 2000 (PubMed).

Whiteland, Nicholls, Shimeld et al.: "Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 43, Issue 3, pp. 313-20, 1995 (PubMed).

Beller, Springer, Schreiber: "Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor." in: The Journal of experimental medicine, Vol. 156, Issue 4, pp. 1000-9, 1983 (PubMed).

Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Springer, Galfré, Secher et al.: "Mac-1: a macrophage differentiation antigen identified by monoclonal antibody." in: European journal of immunology, Vol. 9, Issue 4, pp. 301-6, 1979 (PubMed).

Springer, Galfrè, Secher et al.: "Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens." in: European journal of immunology, Vol. 8, Issue 8, pp. 539-51, 1978 (PubMed).

Catalog No. ABIN118146
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