Interleukin 5 (IL5) antibody

Details for Product No. ABIN118519
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Antigen
Synonyms IL5, Il-5, IL-5, TRF, EDF, Pro-TRH
Reactivity
Guinea Pig, Human, Mouse (Murine)
(90), (64), (16), (2), (1)
Host
Rat
(62), (57), (6), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(27), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
(88), (73), (25), (12), (11), (10), (7), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN118519
731.50 $
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Immunogen Purified natural murine IL-5.
Clone TRFK5
Isotype IgG1
Specificity This antibody is specific for Interleukin 5 (IL-5). Clone TRFK5 may be used to neutralise IL-5 bioactivity in a functional assay (1,2).
Purification Affinity chromatography on Protein G
Alternative Name Interleukin-5 / IL5
Background IL-5 is a T cell derived haematopoietic growth factor, which stimulates eosinophil differentiation and activation.
Alternate names: B-cell differentiation factor I, Eosinophil differentiation factor, IL-5, T-cell replacing factor, TRF
Gene ID 3567
NCBI Accession NP_000870
UniProt P05113
Application Notes Flow Cytometry: Membrane permeabilisation is required for this application. ELISA: This antibody may be used in combination with clone TRFK4 (ABIN181863) in ELISA and ELISPOT assays. Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Schumacher, OGarra, Shrader et al.: "The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 5, pp. 1576-81, 1988 (PubMed).

General Abrams, Roncarolo, Yssel et al.: "Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples." in: Immunological reviews, Vol. 127, Issue 9-10, pp. 5-24, 1992 (PubMed).

Betz, Fox: "Regulation and development of cytochrome c-specific IL-4-producing T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 4, pp. 1046-52, 1990 (PubMed).

Akdis, Akdis, Blesken et al.: "Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro." in: The Journal of clinical investigation, Vol. 98, Issue 7, pp. 1676-83, 1996 (PubMed).

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