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Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibody (PE)

Antigen

Natural Cytotoxicity Triggering Receptor 1 (NCR1)
Clonality Monoclonal (AKS1)
Host
Alternatives

Mouse
Reactivity
Alternatives

Cow (Bovine)
Conjugate
Application
Alternatives Flow Cytometry (FACS)
3 references available
Catalog no. ABIN120215
Quantity 100 Tests  (0.1 mg/ml)
Price 649.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives back to top

Alternative name CD335 / NKp46
UniProt Q863H2
Immunogen Fusion protein consisting of the extracellular region of bovine CD335. Spleen cells from immunised Balb/c mice were fused with cells of the NS-0 myeloma cell line
Cross-Reactivity Cow (Bovine)
Isotype IgG1
Clone AKS1
Description CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is primarily expressed by a subset natural killer (NK) cells. No expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. Alternate Names: NKp46, Natural cytotoxicity triggering receptor 1.
Specificity This antibody is specific for CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.

Application Details
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Application Notes Flow Cytometry: neat- 1/5, use 10 ul of the suggested working dilution to label 106 cells in 100 ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.1 mg/ml
Buffer PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Storage Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf Life: one year from despatch.Reconstitution: Restore with 1 ml distilled water.
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Storset, Slettedal, Williams et al.: "Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs." in: European journal of immunology, Vol. 33, Issue 4, pp. 980-90, 2003 (PubMed).

Storset, Kulberg, Berg et al.: "NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics." in: European journal of immunology, Vol. 34, Issue 3, pp. 669-76, 2004 (PubMed).

Kulberg, Boysen, Storset: "Reference values for relative numbers of natural killer cells in cattle blood." in: Developmental and comparative immunology, Vol. 28, Issue 9, pp. 941-8, 2004 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Natural Cytotoxicity Triggering Receptor 1 (NCR1)", type "Antibodies"
Hosts Rabbit (48), Mouse (23), Goat (1)
Reactivities Human (70), Cow (Bovine) (45), Mouse (Murine) (38), Rat (Rattus) (38), Dog (Canine) (37), Horse (Equine) (36), Pig (Porcine) (36), Sheep (Ovine) (36), Cat (Feline) (1), Chicken (1)
Applications Flow Cytometry (FACS) (38), Western Blotting (WB) (37), Immunofluorescence (IF) (33), ELISA (21), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Functional Studies (Func) (4), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (IHC) (2), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1)
Conjugates PE (5), FITC (4), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), RPE (1), Un-conjugated (1)
Epitopes AA 131-200 (18), C-Term (2), N-Term (2), AA 22-255 (1), Internal Region (1)