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Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibody (PE)

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Synonyms CD335, LY94, NK-p46, NKP46, Ly94, NKp46, KILR-1, Nk-p46, Nkp46
Cow (Bovine)
(105), (63), (19), (16), (4), (4), (3), (3), (2), (1)
(78), (44), (40), (2)
Clonality (Clone)
Monoclonal ()
(19), (12), (8), (8), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(100), (62), (18), (16), (12), (11), (8), (7), (7), (6), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 100 tests
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Fusion protein consisting of the extracellular region of bovine CD335. Spleen cells from immunised Balb/c mice were fused with cells of the NS-0 myeloma cell line.
Clone AKS1
Isotype IgG1
Specificity This antibody is specific for CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.
Purification Affinity Chromatography on Protein G.
Alternative Name CD335 / NKp46 (NCR1 Antibody Abstract)
Background CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is primarily expressed by a subset natural killer (NK) cells. No expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes.Synonyms: LY94, NCR1, NK cell-activating receptor, NKp46, Natural cytotoxicity triggering receptor, Natural killer cell p46-related protei
Gene ID 369024
NCBI Accession NP_899209
UniProt Q863H2
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: neat- 1/5, use 10 μL of the suggested working dilution to label 106 cells in 100 μL. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Lyophilized and reconstituted antibody ist stable at 2 - 8 °C for up to one month or at -20 °C for longer.
Background publications Kulberg, Boysen, Storset: "Reference values for relative numbers of natural killer cells in cattle blood." in: Developmental and comparative immunology, Vol. 28, Issue 9, pp. 941-8, 2004 (PubMed).

Storset, Kulberg, Berg et al.: "NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics." in: European journal of immunology, Vol. 34, Issue 3, pp. 669-76, 2004 (PubMed).

Storset, Slettedal, Williams et al.: "Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs." in: European journal of immunology, Vol. 33, Issue 4, pp. 980-90, 2003 (PubMed).

Catalog No. ABIN120215
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