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Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibody (PE)
Alternatives Flow Cytometry (FACS)
|3 references available|
|Quantity||100 Tests (0.1 mg/ml)|
|Price||649.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||CD335 / NKp46|
|Immunogen||Fusion protein consisting of the extracellular region of bovine CD335. Spleen cells from immunised Balb/c mice were fused with cells of the NS-0 myeloma cell line|
|Description||CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is primarily expressed by a subset natural killer (NK) cells. No expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. Alternate Names: NKp46, Natural cytotoxicity triggering receptor 1.|
|Specificity||This antibody is specific for CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.|
|Application Notes||Flow Cytometry: neat- 1/5, use 10 ul of the suggested working dilution to label 106 cells in 100 ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin|
|Storage||Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf Life: one year from despatch.Reconstitution: Restore with 1 ml distilled water.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Restrictions||For Research Use only|
Storset, Slettedal, Williams et al.: "Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs." in: European journal of immunology, Vol. 33, Issue 4, pp. 980-90, 2003 (PubMed).
Storset, Kulberg, Berg et al.: "NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics." in: European journal of immunology, Vol. 34, Issue 3, pp. 669-76, 2004 (PubMed).
Kulberg, Boysen, Storset: "Reference values for relative numbers of natural killer cells in cattle blood." in: Developmental and comparative immunology, Vol. 28, Issue 9, pp. 941-8, 2004 (PubMed).